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Organic Clary Sage Oil

Healthy Mood Support*
Calms Nerves*
Stimulates Sexual Desire*
Hair & Skin Support*
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Product Information

Salvia sclarea (also known as Clary Sage Oil) is mostly found in Mediterranean Europe. It is one of the most valued aromatic herbs due to its abundance of essential oils. *

What is Clary Sage Oil?

Sage Oil (meaning “to heal” in Latin) is widely used in the culinary, and cosmetics industry. Sage Oil is renowned for its many health properties, i.e. skin health, antioxidant support, blood sugar management, mood health, calming and cell homeostatis support[1]. It is traditionally used to support of a range of health benefits including digestive and circulation health, respiratory health, cold and flu support, sleep health, memory support, cell homeostatis, mood support and, temperature control. Sage Oil is used as a brain tonic to enhance head and brain functions, memory support, boost the senses, and support age-associated cognitive performance [2]. *

  • Cognition refers to mental actions associated with acquiring knowledge. It encompasses processes associated with attention, memory, judgment and evaluation, reasoning, problem-solving and decision making. The cognitive-enhancing efficacy of Sage Oil is promising. The results from several human trials indicated significantly greater improvements in cognitive function [3]. There were statistically significant boosts in cognition and increased alertness in patients who were supplemented with capsules containing 50 µL of Sage Oil [4].*
  • The administration of Sage Oil (less than 50 microl) resulted in a consistent improvement in the speed factor of memory. There was also an improvement on the factor for secondary memory. Moods were consistently enhanced, with increases in self-rated alertness, calmness, and contentedness [5]. Depression and chronic stress can have deleterious effects on cognitive performance. The administration of hydroalcoholic extract from Sage Oil has been proven to produce calming and relaxation effects via animal models [6]. The phenolic acids, rosmarinic acid, and caffeic acid were attributed to the mood enhancing and calming benefits of Sage Oil.*
  • Sage Oil possesses excellent cell homeostatis properties. Acute cell stress induced by intraperitoneal administration of turpentine oil in mice was significantly managed by Sage Oil tincture as demonstrated by reductions in total leukocyte and monocyte percentages as well as the activation of circulating phagocytes [7].*
  • Oxidative stress has been linked to many neurological disorders, including Alzheimer’s disease and Parkinson’s disease. The Salvia plant and its individual constituents possess strong antioxidant properties [8]. A majority of the antioxidant effects are attributed to phenolic compounds such as rosmarinic acid, salvianolic acid, sagecoumarin and sagerinic acid as they exhibit strong radical scavenging activities with approximately 90% of 2,2-diphenylpicrylhydrazyl (DPPH) scavenged under experimental conditions. In fact, their effects were substantially greater than Sage Oil flavonoids, luteolin and apigenin [9].*
  • Neurotrophins are important regulators of neural survival, development, and function. Brain-derived neurotrophic factor levels were confirmed to be lower in patients with Alzheimer’s disease and those with mild cognitive impairment. Administration of Sage Oil helps to support memory and brain health and increase brain-derived neurotrophic factor levels [10]. In vitro and animal studies have revealed that several Salvia plant species and their constituents are effective acetylcholinesterase inhibitors that can improve neuron and cognitive functions [11]. The accumulation of amyloid-β peptide is a characteristic of Alzheimer’s disease and these deposits are considered partially responsible for the cognitive dysfunction seen in Alzheimer’s disease. Sage Oil has been proven to protect mice from Aβ-induced neurotoxicity by supporting the management of toxins and tissue masses [12].*
  • Sage Oil possesses promising bacterial support properties. It showed equal bacteriostatic and bactericidal activity. Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacteria (Escherichia coli, Salmonella typhimurium, Klebsiella pneumonia, Pseudomonas aeruginosa, and Bacillus pumilus) [13] are a problem. Sage Oil supports healthy cell membrane permeability, leading to healthy release of cytoplasms such as macromolecular substances, ATP and DNA.*
  • A study by Dźamić et al. displayed the healthy fungal support activity of Sage Oil. Fungus like Aspergillus, Penicillium, Fusarium, Trichoderma, Mucor, Candida and also fungicidal activities such as Cladosporium, Trichophyton, Alternaria, and Phoma [14] can occur in the human body. Due to the strong fungal health properties of Sage Oil, it can be used to support skin health.*
  • Leishmaniasis, the third most important vector-borne disease, is caused by a protozoan parasite of the genus Leishmania. Sage Oil displays potential parasite health support [15]. The Salvia species has excellent cell reproduction promoting effects. Human promyelocytic leukemia cells, erythroleukemia cells, and breast cancer cells are all as a result of the replication of damaged cells [16].*

Nutritional Value or Phytochemical Content

Sage Oil is a rich source of polyphenol compounds, with over 160 identified polyphenols comprising an array of phenolic acids and flavonoids. These phenolic compounds include caffeic acid and its derivatives, rosmarinic acid, salvianolic acids, sagecoumarin, lithospermic acids, sagernic acid, and yunnaneic acids. The most prevalent flavonoids include luteolin, apigenin, hispidulin, kaempferol, and quercetin. Plants of the genus Salvia are also rich in essential oils, with a large array of terpenoids including α and β-thujone, camphor, 1,8-cineole, α-humulene, β-caryophyllene, and viridiflorol. Moreover, it is a rich source of diterpenes and triterpenes such as carnosic acid, ursolic acid, carnosol, and tanshinones.

Suggested Usage / Dosage

Internal Use - High-food grade oil or 100% therapeutic grade oil (50 µL) is used.

External Use - Example of best carrier oil: Coconut oil is used along with 3 - 5 drops of Sage Oil (used for hair massage, skin care, abdominal and joint pain, and stress therapy).

Ideal Storage Conditions

Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.

Shelf Life

2 years from Date of Manufacture.

References

  1. Rajabia Z, Ebrahimia M, Farajpoura M, Mirzac M, Ramshini H. Compositions and yield variation of essential oils among and within nine Salvia species from various areas of Iran. Ind Crop Prod. 2014;61:233–239.
  2. Medicinal plants and Alzheimer's disease: from ethnobotany to phytotherapy. Perry EK, Pickering AT, Wang WW, Houghton PJ, Perry NS J Pharm Pharmacol. 1999 May; 51(5):527-34.
  3. Lopresti, Adrian L. “Salvia (Sage): A Review of Its Potential Cognitive-Enhancing and Protective Effects.” Drugs in R&D 17.1 (2017): 53–64. PMC. Web. 22 Jan. 2018.
  4. Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav. 2003;75(3):651–659.
  5. Tildesley NT, Kennedy DO, Perry EK, Ballard CG, Wesnes KA, Scholey AB. Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers. Physiol Behav. 2005;83(5):699–709.
  6. Chronic food administration of Salvia sclarea oil reduces animals' anxious and dominant behavior. Gross M, Nesher E, Tikhonov T, Raz O, Pinhasov A J Med Food. 2013 Mar; 16(3):216-22.
  7. Effects of Salvia officinalis L. extract on experimental acute inflammation. Oniga I, Pârvu AE, Toiu A, Benedec D. Rev Med Chir Soc Med Nat Iasi. 2007 Jan-Mar; 111(1):290-4.
  8. Comprehensive Evaluation of Antioxidant Potential of 10 Salvia Species Using High Pressure Methods for the Isolation of Lipophilic and Hydrophilic Plant Fractions. Šulniūtė V, Ragažinskienė O, Venskutonis PR. Plant Foods Hum Nutr. 2016 Mar; 71(1):64-71.
  9. Lu Y, Foo Y. Antioxidant activities of polyphenols from sage (Salvia officinalis) Food Chem. 2001;75:197–202.
  10. Rosmarinic acid prevents against memory deficits in ischemic mice. Fonteles AA, de Souza CM, de Sousa Neves JC, Menezes AP, Santos do Carmo MR, Fernandes FD, de Araújo PR, de Andrade GM Behav Brain Res. 2016 Jan 15; 297():91-103.
  11. Acetylcholinesterase inhibitors: pharmacology and toxicology. Colović MB, Krstić DZ, Lazarević-Pašti TD, Bondžić AM, Vasić VM. Curr Neuropharmacol. 2013 May; 11(3):315-35.
  12. Compound danshen tablet ameliorated aβ25-35-induced spatial memory impairment in mice via rescuing imbalance between cytokines and neurotrophins. Teng Y, Zhang MQ, Wang W, Liu LT, Zhou LM, Miao SK, Wan LH BMC Complement Altern Med. 2014 Jan 14; 14():23.
  13. Cui, Haiying et al. “Antimicrobial Activity and Mechanisms of Salvia Sclarea Essential Oil.” Botanical Studies 56 (2015): 16. PMC. Web. 22 Jan. 2018.
  14. Dźamić A, Sokovic M, Ristic M, et al. Chemical composition and antifungal activity of Salvia sclarea (Lamiaceae) essential oil. Arch Biol Sci. 2008;60:233–7. [
  15. Mehmood S, Ahmad Z, Malik A, Afza N. Phytochemical studies on Salvia santolinifolia. J. Chem. Soc. Pakistan. 2008;30:311–314.
  16. Firuzi, Omidreza et al. “Cytotoxic, Antioxidant and Antimicrobial Activities and Phenolic Contents of Eleven Salvia Species from Iran .” Iranian Journal of Pharmaceutical Research : IJPR 12.4 (2013): 801–810. Print.

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