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Pine Bark 95% Extract

Powerful Antioxidant*
Blood Sugar Support*
Supports Healthy Skin*
Assists Natural Healing*
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Product Information

Pinus massoniana belong to Pinaceae family is native to Taiwan and China.

What is Pine Bark Extract?

Pine Bark extract is rich in proanthocyanidins, a special class of water-soluble powerful antioxidant flavonoids, which are an excellent free radical scavenger and helps to support a healthy immune system. Pine bark has been used in traditional Chinese medicine to support aches and pains, healthy cell formation and healthy immune response [1]. Masson's pine, Chinese red pine, horsetail pine are some of the common name given to this plant. Pine trees are widely distributed worldwide being with around 105 species the largest genus of conifers. Consumption of various parts, including needles, bark, cones, and pollen is believed to promote health and support a range of healthy aging benefits [18]. *

How Could Pine Bark Extract Support My Health?

Pine bark has been traditionally used as food and medicine for more than 2000 years. In ancient times, pine bark was used to support aches, pain and healthy infIammation response. European herbals of the fifteenth and sixteenth century mention the efficacy of pine bark in to support skin and wound health. In North America, indigenous people used pine bark to support healthy vitamin c levels. It is worthwhile to note that the older bark was often used for therapeutic purposes, while the younger bark was used as food. In addition, in northern Scandinavia, Sami people used pine inner bark as food [15, 16]. *

Pine bark is rich in polysaccharide which is an excellent immunomodulatory agent. These polysaccharides represent an unlimited resource because of their various biological activities [2]. It has been used as dietary supplement in traditional medicine for centuries for alleviating fatigue and supporting energy [3]. *

Apart from supporting a healthy immune system, the polysaccharide significantly support healthy cell formation [4]. The non-toxic flavonoid from pine bark has viral support and promotes a healthy liver [5]. It also selectively induces apoptosis in human hepatoma cells (mutated liver cell formation), possibly through caspase-dependent pathways [6]. *

Zhang et al., 2012 studied Pine bark and suggested that Pine bark supports healthy tumor cells by inducing cell apoptosis and improving lymphoproliferation [7]. *

[9]. Liu et al., 2015 investigated the tumor supporting effect of Pinus massoniana bark proanthocyanidins on ovaries. The results indicated that Pine bark significantly supports healthy ovaries through dose-dependent apoptosis but did not affect normal ovarian cells. The underlying mechanisms involved were elucidated to include the loss of mitochondrial membrane potential, down-regulation of the anti-apoptotic protein Bcl-2 and the activation of Caspase 3/9, suggesting that PMBPs triggered apoptosis through activation of the mitochondria-associated apoptotic pathway [10]. Some studies have revealed that Pinus massoniana bark extract supports cervical health (Hela cells) [11] [13]. *

Lung cancer is one of the most prevalent types of malignant tumor, with 1.83 million new diagnoses per year worldwide, and is a leading cause of cancer-associated mortality globally. Due to the difficulty in determining an early diagnosis and the high metastatic potential of this form of cancer, metastasis develops prior to the diagnosis of lung cancer in the majority of cases. Approximately 90% of patients with lung cancer succumb to the disease due to tumor metastasis. P. massoniana bark extracts support healthy lungs and cell growth [14]. *

The essential oil from Pine bark exhibits some potential as a healthy irregular cell growth support [20]. *

Its natural antioxidant activity, superoxide anion radical scavenging and free radical scavenging activities were the reason or as a candidate precursor substance for new health remedies [12]. They have also been shown to be a very powerful antioxidant and free radical-scavenger, even more, powerful than either vitamin C or vitamin E. *

One of the amazing property of the polysaccharide is could be used as an immunoadjuvant, i.e., significantly support the effects of different health remedies [8]. *

Human studies have proved that Pycnogenol (procyanidins) has beneficial effects in cardiovascular health, respiratory health, muscle aches, bacteria health, cognitive health, skin health and sexual function [17]. *

Pine polyphenols are bioactive dietary constituents that enhance health and help support health through antioxidants. It supports healthy blood, liver and spleen. Pine polyphenols reduce lipid peroxidation and decrease the level of oxidative damages caused by ionizing radiation. In addition, it significantly supports healthy white blood cells, red blood cells, and platelets counts and increases the activities of superoxide dismutase, catalase and glutathione peroxidases, and the level of glutathione [19]. *

Nutritive Value or Phytochemical Content

Pine bark extracts have been intensively investigated with regard to their chemical constituents. It contains numerous phenolic compounds such as polyphenolic monomers, procyanidins, and phenolic acids. It is rich in proanthocyanidins, known as oligomeric proanthocyanidins or condensed tannins which represent a group of condensed flavan-3-ols, such as procyanidins, prodelphinidins, and propelargonidins. The most widely studied proanthocyanidins are based on flavan-3-ol (-)-epicatechin and (+)-catechin. *

Suggest Usage / Dosage

Take 80 - 120mg of our extract daily.

Ideal Storage Conditions

Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.

Shelf Life

Two years from date of manufacture.

References

  1. Potential biomedical properties of Pinus massoniana bark extract. Cui Y, Xie H, Wang J Phytother Res. 2005 Jan; 19(1):34-8.
  2. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Ooi VE, Liu F Curr Med Chem. 2000 Jul; 7(7):715-29.
  3. He XY, Sun XY, Yu ZY (2007) Effective components and pharmacological punction of pine pollen. Journal of Northeast Forestry University 35: 78–80.
  4. Yang S, Wei K, Jia F, et al. Characterization and Biological Activity of Taishan Pinus massoniana Pollen Polysaccharide In Vitro. Russell CJ, ed. PLoS ONE. 2015;10(3):e0115638. doi:10.1371/journal.pone.0115638.
  5. Wang C, Zhang L, Cheng P, Zhang Q. Inhibitory effects of Pinus massoniana bark extract on hepatitis C virus in vitro. Pharm Biol. 2015;53(3):451-456. doi:10.3109/13880209.2014.924018.
  6. Ma H, Liu B, Feng D, et al. Pinus massoniana bark extract selectively induces apoptosis in human hepatoma cells, possibly through caspase-dependent pathways. Int J Mol Med. 2010;25(5):751-759.
  7. Zhang J-H, Feng D-R, Ma H-L, et al. Antitumor effects of Pinus massoniana bark extract in murine sarcoma S180 both in vitro and in vivo. Am J Chin Med. 2012;40(4):861-875. doi:10.1142/S0192415X12500644.
  8. Effects of Taishan Pinus massoniana pollen polysaccharide on immune response of rabbit haemorrhagic disease tissue inactivated vaccine and on production performance of Rex rabbits. Wei K, Sun Z, Yan Z, Tan Y, Wang H, Zhu X, Wang X, Sheng P, Zhu R Vaccine. 2011 Mar 21; 29(14):2530-6.
  9. Proceedings: Grading of gynecologic malignancy: epithelial ovarian cancer. Decker DG, Mussey E, Williams TJ, Taylor WF Proc Natl Cancer Conf. 1972; 7():223-31.
  10. Liu J, Bai J, Jiang G, et al. Anti-Tumor Effect of Pinus massoniana Bark Proanthocyanidins on Ovarian Cancer through Induction of Cell Apoptosis and Inhibition of Cell Migration. Hsieh Y-H, ed. PLoS ONE. 2015;10(11):e0142157. doi:10.1371/journal.pone.0142157.
  11. Involvement of the Bcl-2 family members in Pinus massoniana bark extract induced apoptosis in HeLa cells. Ma H, Lai F, Xie H, Wang J, Wang H Phytother Res. 2008 Nov; 22(11):1472-6.
  12. Cui Y, Xie H, Wang J. Potential biomedical properties of Pinus massoniana bark extract. Phytother Res. 2005;19(1):34-38. doi:10.1002/ptr.1619.
  13. Hsu TY, Sheu SC, Liaw ET, Wang TC, Lin CC. Anti-oxidant activity and effect of Pinus morrisonicola Hay. on the survival of leukemia cell line U937. Phytomedicine. 2005;12(9):663-669. doi:10.1016/j.phymed.2004.03.013.
  14. Mao P, Zhang E, Chen Y, et al. Pinus massoniana bark extract inhibits migration of the lung cancer A549 cell line. Oncology Letters. 2017;13(2):1019-1023. doi:10.3892/ol.2016.5509.
  15. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol.Packer L, Rimbach G, Virgili F Free Radic Biol Med. 1999 Sep; 27(5-6):704-24.
  16. A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract.Maimoona A, Naeem I, Saddiqe Z, Jameel K J Ethnopharmacol. 2011 Jan 27; 133(2):261-77.
  17. Pycnogenol: a blend of procyanidins with multifaceted therapeutic applications? D'Andrea G Fitoterapia. 2010 Oct; 81(7):724-36. 18. Antioxidant, antimutagenic, and antitumor effects of pine needles (Pinus densiflora).Kwak CS, Moon SC, Lee MS Nutr Cancer. 2006; 56(2):162-71.
  18. Li H, Wang Z, Xu Y, Sun G. Pine polyphenols from Pinus koraiensis prevent injuries induced by gamma radiation in mice. Ng TB, ed. PeerJ. 2016;4:e1870. doi:10.7717/peerj.1870.
  19. Hoai NT, Duc HV, Thao DT, Orav A, Raal A. Selectivity of Pinus sylvestris extract and essential oil to estrogen-insensitive breast cancer cells Pinus sylvestris against cancer cells. Pharmacognosy Magazine. 2015;11(Suppl 2):S290-S295. doi:10.4103/0973-1296.166052.

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