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Cats Claw (10:1) Extract

Boosts Immune System*
Assists Joint Mobility*
Healthy Cell Production*
Supports Healthy DNA*
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Product Information

Uncaria tomentosa (a woody vine found in the Amazon rainforest) is popularly known as "Cat's Claw" because of its claw-shaped thorns.

What is Cat's Claw?

Cat's Claw (also known as vilcacora) derives its name from the Indian language of the Quechua people to mean a "sacred plant". Cat's claw has been used in traditional health practices and can be found in the forests of South America (mainly Peru and Brazil) and in Central America. Currently, Cat's Claw is used in Western countries as a nutritional supplement for a variety of health conditions. It is also used to support the immune system and as a support herb for viral health. HIV and herbes are believed to be viral infections. *

  • Cat's Claw may encourage white blood cells to inhibit the lipopolysaccharide (LPS)-dependent expression or in simple terms support healthy cell reproduction [4]. Alkaloids, quinovic acid, α-glycosides and β-sitosterol from Cat’s Claw interact synergistically and exhibit flammation homeostatis promoting properties [5]. Several water-soluble flavonoids like procyanidines, quercetin, ursolic acid, and oleanoic acid found in Cat’s Claw my offer breath support, and antioxidant and healthy cell promoting properties [6].*
  • Cat's Claw is also considered a great cancer support agent [7]. Breast cancer is the most frequent neoplasm affecting women worldwide. Some recommended treatments involve chemotherapy, with toxic effects that include leukopenia and neutropenia. Cat’s Claw may support the bodies ability to manage and reproduce healthy dna. It is an effective adjuvant agent to support healthy breast cells [17].*
  • The stem and bark of Cat's Claw help to support healthy glycemic levels and blood sugar. An extract concentration of 400 mg/kg showed a high support of blood sugar management (by 15%) [8]*
  • One of the astounding properties of Cat's Claw is its support for microbial management. There are many different pathogens such as Streptococcus mutans, Staphylococcus spp, Pseudomonas aeruginosa, Candida albicans and Enterobacteriaceae. Cat’s Claw supported 8% of healthy Enterobacteriaceae isolates, 52% of healthy Streptococcus mutans and 96% of healthy Staphylococcus spp at the concentration of 30 mg/ml. Healthy bacterial management activity was associated with oxindole alkaloids, triterpene, vegetal steroids, phenolic compounds, glycoside, tannin, and flavonoids. Pheophorbide an ethyl ester, Uncarine E, rhynchophylline, and isorhynchophylline (isolated from Cat’s Claw) also showed significant healthy bacterial support [9][10][11] healthy HIV management. Cat's Claw demonstrates no adverse effects when taken with antiretrovirals [19]. *
  • Several studies have also demonstrated the relationship between indole alkaloids and healthy nerve and stress response [12].*
  • Cat’s Claw shows promise in providing healthy support for the central nervous system (CNS). Investigations have suggested that Cat’s Claw extract ameliorates amyloid-β-induced neuronal death, methampheta**ne-induced cortical neuron death, glutamate-induced cell death and hippocampal cell death [13]. Cat's Claw extract supports our learning ability and may boost memory. It may also assist with brain health and as a mood support.*
  • Parkinson's disease is a degenerative nerve disease characterized by a decrease in neurotransmitter levels. The aqueous extract of Cat's Claw has a positive neuroprotective effect on dopaminergic neurons [14]. Results showed that the extract has free radical scavenging abilities, attenuates 6-OHDA-induced cell death (massive destruction of nigrostriatal dopaminergic neurons) and inhibits the activation of nitric oxide synthase and NF-κβ. This suggested that Ca's Claw is a potential neuroprotective antioxidant in the preservation of brain health.*
  • Alzheimer’s disease is a multifaceted neurodegenerative disorder characterized by the deterioration of cognition, learning ability, and memory that might be delayed by acetylcholinesterase inhibitors [15]. Cat's Claw extract has a significant effect on increasing acetylcholine and glutathione levels and decreasing acetylcholinesterase. Isorhynchophylline constituents (derived from Cat's Claw) can enhance the antioxidant and provide positive homeostatis effects on brain tissue [16].*
  • Recent studies support the use of Uncaria tomentosa alone or in combination with other medicinal herbs for joint health [18]. It was discovered that pain-associated activities of daily living were significantly reduced. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and visual analog scale (VAS) scores were improved after 8 weeks of this supplement when compared with placebos.*

Nutritive Value and Bioactive Constituents

The chemical constituents of Cat’s Claw have been extensively studied since the early 1900s. More than 200 compounds have been isolated from Uncaria tomentosa, including alkaloids, triterpenes, flavonoids, and phenylpropanoids.

123 indole alkaloids have been identified and are classified as monoterpene indole, monoterpene oxindole, and N-oxindole monoterpene indole alkaloids. Of these, oxindole alkaloids are regarded as major components (especially rhynchophylline and iso-rhynchophylline), as well as the corresponding unsaturated oxindole alkaloids like corynoxeine and isocorynoxeine. 82 triterpenoids have been isolated from this genus and quinovic acid is a common compound. 40 flavonoids have been identified from the Uncaria tomentosa which are classified to be flavan-3-ols and flavonols.

Suggested Usage / Dosage

The recommended dosage for this extract is 300 mg daily.

Interactions / Side Effects

No side effects or pharmaceutical interaction or toxicity has been observed.

Ideal Storage Conditions

Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.

Shelf Life

2-years from Date of Manufacture.

References

  1. Medicinal uses, phytochemistry and pharmacology of the genus Uncaria. Zhang Q, Zhao JJ, Xu J, Feng F, Qu W. J Ethnopharmacol. 2015 Sep 15; 173():48-80.
  2. HPLC analysis of oxindole alkaloids in Uncaria tomentosa: sample preparation and analysis optimisation by factorial design.Bertol G, Franco L, Oliveira BH Phytochem Anal. 2012 Mar-Apr; 23(2):143-51.
  3. Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Sandoval M, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJhytomedicine. 2002 May; 9(4):325-37.
  4. Antiinflammatory actions of cat's claw: the role of NF-kappaB. Sandoval-Chacón M, Thompson JH, Zhang XJ, Liu X, Mannick EE, Sadowska-Krowicka H, Charbonnet RM, Clark DA, Miller MJ Aliment Pharmacol Ther. 1998 Dec; 12(12):1279-89.
  5. Yuan,D.,Ma,B.,Wu,C.,Yang,J.Y.,Zhang,L.J.,Liu,S.K.,Wu,L.J.,Kano,Y.,2008. Alkaloids fromtheleavesof Uncaria rhynchophylla and theirinhibitoryonNO productioninlipopolysaccharide-activiatedmicroglia.JournalofNatural Products71,1271–1274.
  6. Vilcacora [Uncaria tomentosa (Willd.) DC. and Uncaria guianensis (Aublet) Gmell.] – a review of published scientific literature
  7. Medicinal uses,phytochemistry and pharmacology of the genus Uncaria. J Ethnopharmacol. 2015 Sep 15;173:48-80. doi: 10.1016/j.jep.2015.06.011. Epub 2015 Jun 17.
  8. Domingues, A.,Sartori,A.,Golim,M.A.,Valente,L.M.,DaRosa,L.C.,Ishikawa,L.L., Siani, A.C.,Viero,R.M.,2011.Preventionofexperimentaldiabetesby Uncaria tomentosa extract:Th2polarization,regulatoryTcellpreservationorboth? Journal ofEthnopharmacology137,635–642.
  9. Ccahuana-Vasquez, R.A., Santos, S.S., Koga-Ito, C.Y., Jorge, A.D., 2007. Antimicrobial activity of Uncaria tomentosa against oral human pathogens. Brazilian Oral Research 21, 46–50.
  10. Aquino, R., De Tommasi, N., De Simone, F., Pizza, C., 1997. Triterpens and quinovic acid glycosides from Uncaria tomentosa. Phytochemistry 45, 1035–1040.
  11. Chen, X., Xu, J., Mu, X., Hu, Y., Hu, G., Duan, H., Zhang, T., Lin, H., Zhang, W., 2010. Effects of rhynchophylline and isorhynchophylline on nitric oxide and endothelin-1 secretion from RIMECs induced by Listeriolysin O in vitro. Veter- inary Microbiology. 143, 262–269.
  12. Song, C.Q., Fan, Y., Huang, W.H., Wu, D.Z., Hu, Z.B., 2000. Different hypotentive effects of various active constituents isolated from Uncaria rhynchophylla. Chinese Traditional and Herbal Drugs 31, 762–764, in chinese.
  13. Jung, H.Y.,Nam,K.N.,Woo,B.C.,Kim,K.P.,Kim,S.O.,Lee,E.H.,2013.Hirsutine,an indole alkaloidof Uncaria rhynchophylla, inhibitsinflammation-mediated neurotoxicityandmicroglialactivation.MolecularMedicineReports7, 154–158.
  14. Shi, J.S.,Wu,Q.,Liu,G.X.,1989.Heamodynamiceffectofrhynchophyllineonthe conscious rat.GuizhouMedicalJournal13,72–73.
  15. Acetylcholin esterase inhibitors from plants and fungi.Natural Product Reports 23,181–199.
  16. Xian, Y.F.,Mao,Q.Q.,Wu,J.C.,Su,Z.R.,Chen,J.N.,Lai,X.P.,Ip,S.P.,Lin,Z.X.,2014. Isorhynchophyllinetreatmentimprovestheamyloid-beta-inducedcognitive impairment inratsviainhibitionofneuronalapoptosisandtauprotein hyperphosphorylation.JournalofAlzheimer’s Disease39,331–346.
  17. Santos Araujo M do C, Farias IL, Gutierres J, et al. Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:676984. doi:10.1155/2012/676984.
  18. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis.Piscoya J, Rodriguez Z, Bustamante SA, Okuhama NN, Miller MJ, Sandoval M Inflamm Res. 2001 Sep; 50(9):442-8.
  19. Dietary supplement interactions with antiretrovirals: a systematic review.International journal of STD & AIDS. LID - 10.1177/0956462416671087 [doi]

 

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