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Cats Claw (10:1) Extract

Boosts Immune System*
Assists Joint Mobility*
Healthy Cell Production*
Supports Healthy DNA*
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Product Information

Uncaria tomentosa (a woody vine found in the Amazon rainforest) is popularly known as "Cat's Claw" because of its claw-shaped thorns.

What is Cat's Claw?

Cat's Claw (also known as vilcacora) derives its name from the Indian language of the Quechua people to mean a "sacred plant". Cat's claw has been used in traditional health practices and can be found in the forests of South America (mainly Peru and Brazil) and in Central America. Currently, Cat's Claw is used in Western countries as a nutritional supplement for a variety of health conditions. It is also used to support the immune system and as a support herb for viral health. HIV and herbes are believed to be viral infections. *

Nutritive Value and Bioactive Constituents

The chemical constituents of Cat’s Claw have been extensively studied since the early 1900s. More than 200 compounds have been isolated from Uncaria tomentosa, including alkaloids, triterpenes, flavonoids, and phenylpropanoids.

123 indole alkaloids have been identified and are classified as monoterpene indole, monoterpene oxindole, and N-oxindole monoterpene indole alkaloids. Of these, oxindole alkaloids are regarded as major components (especially rhynchophylline and iso-rhynchophylline), as well as the corresponding unsaturated oxindole alkaloids like corynoxeine and isocorynoxeine. 82 triterpenoids have been isolated from this genus and quinovic acid is a common compound. 40 flavonoids have been identified from the Uncaria tomentosa which are classified to be flavan-3-ols and flavonols.

Suggested Usage / Dosage

The recommended dosage for this extract is 300 mg daily.

Interactions / Side Effects

No side effects or pharmaceutical interaction or toxicity has been observed.

Ideal Storage Conditions

Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.

Shelf Life

2-years from Date of Manufacture.

References

  1. Medicinal uses, phytochemistry and pharmacology of the genus Uncaria. Zhang Q, Zhao JJ, Xu J, Feng F, Qu W. J Ethnopharmacol. 2015 Sep 15; 173():48-80.
  2. HPLC analysis of oxindole alkaloids in Uncaria tomentosa: sample preparation and analysis optimisation by factorial design.Bertol G, Franco L, Oliveira BH Phytochem Anal. 2012 Mar-Apr; 23(2):143-51.
  3. Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Sandoval M, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJhytomedicine. 2002 May; 9(4):325-37.
  4. Antiinflammatory actions of cat's claw: the role of NF-kappaB. Sandoval-Chacón M, Thompson JH, Zhang XJ, Liu X, Mannick EE, Sadowska-Krowicka H, Charbonnet RM, Clark DA, Miller MJ Aliment Pharmacol Ther. 1998 Dec; 12(12):1279-89.
  5. Yuan,D.,Ma,B.,Wu,C.,Yang,J.Y.,Zhang,L.J.,Liu,S.K.,Wu,L.J.,Kano,Y.,2008. Alkaloids fromtheleavesof Uncaria rhynchophylla and theirinhibitoryonNO productioninlipopolysaccharide-activiatedmicroglia.JournalofNatural Products71,1271–1274.
  6. Vilcacora [Uncaria tomentosa (Willd.) DC. and Uncaria guianensis (Aublet) Gmell.] – a review of published scientific literature
  7. Medicinal uses,phytochemistry and pharmacology of the genus Uncaria. J Ethnopharmacol. 2015 Sep 15;173:48-80. doi: 10.1016/j.jep.2015.06.011. Epub 2015 Jun 17.
  8. Domingues, A.,Sartori,A.,Golim,M.A.,Valente,L.M.,DaRosa,L.C.,Ishikawa,L.L., Siani, A.C.,Viero,R.M.,2011.Preventionofexperimentaldiabetesby Uncaria tomentosa extract:Th2polarization,regulatoryTcellpreservationorboth? Journal ofEthnopharmacology137,635–642.
  9. Ccahuana-Vasquez, R.A., Santos, S.S., Koga-Ito, C.Y., Jorge, A.D., 2007. Antimicrobial activity of Uncaria tomentosa against oral human pathogens. Brazilian Oral Research 21, 46–50.
  10. Aquino, R., De Tommasi, N., De Simone, F., Pizza, C., 1997. Triterpens and quinovic acid glycosides from Uncaria tomentosa. Phytochemistry 45, 1035–1040.
  11. Chen, X., Xu, J., Mu, X., Hu, Y., Hu, G., Duan, H., Zhang, T., Lin, H., Zhang, W., 2010. Effects of rhynchophylline and isorhynchophylline on nitric oxide and endothelin-1 secretion from RIMECs induced by Listeriolysin O in vitro. Veter- inary Microbiology. 143, 262–269.
  12. Song, C.Q., Fan, Y., Huang, W.H., Wu, D.Z., Hu, Z.B., 2000. Different hypotentive effects of various active constituents isolated from Uncaria rhynchophylla. Chinese Traditional and Herbal Drugs 31, 762–764, in chinese.
  13. Jung, H.Y.,Nam,K.N.,Woo,B.C.,Kim,K.P.,Kim,S.O.,Lee,E.H.,2013.Hirsutine,an indole alkaloidof Uncaria rhynchophylla, inhibitsinflammation-mediated neurotoxicityandmicroglialactivation.MolecularMedicineReports7, 154–158.
  14. Shi, J.S.,Wu,Q.,Liu,G.X.,1989.Heamodynamiceffectofrhynchophyllineonthe conscious rat.GuizhouMedicalJournal13,72–73.
  15. Acetylcholin esterase inhibitors from plants and fungi.Natural Product Reports 23,181–199.
  16. Xian, Y.F.,Mao,Q.Q.,Wu,J.C.,Su,Z.R.,Chen,J.N.,Lai,X.P.,Ip,S.P.,Lin,Z.X.,2014. Isorhynchophyllinetreatmentimprovestheamyloid-beta-inducedcognitive impairment inratsviainhibitionofneuronalapoptosisandtauprotein hyperphosphorylation.JournalofAlzheimer’s Disease39,331–346.
  17. Santos Araujo M do C, Farias IL, Gutierres J, et al. Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:676984. doi:10.1155/2012/676984.
  18. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis.Piscoya J, Rodriguez Z, Bustamante SA, Okuhama NN, Miller MJ, Sandoval M Inflamm Res. 2001 Sep; 50(9):442-8.
  19. Dietary supplement interactions with antiretrovirals: a systematic review.International journal of STD & AIDS. LID - 10.1177/0956462416671087 [doi]

 

* Individual results may vary from person to person.