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Lions Mane 30% Extract

Enhances Brain Function*
Healthy Cell Production*
Improves Digestive Health*
Powerful Antioxidant*
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Product Information

Hericium Erinaceus is known in Asia as an important wellness fungus as well as a health-promoting food. *

What is Lion's Mane?

Hericium Erinaceus (also called Lion's Mane or Yamabushitake mushroom) is consumed as a food in Japan and China. It has attracted much research due to its health benefits as a home remedy for health ailments. Its fruiting bodies and fungal mycelia exhibit various health properties. *

How could Lion's Mane Extract Support My Health?

The physiological systems in the body should be balanced in order to maintain whole-body homeostasis. Once the balance is disturbed, dis-ease can occur. There is increasing evidence to indicate that oxidative stress may affect a myriad of health challenges, including cancer and Alzheimer's. Reactive oxygen species (ROS) and lipid peroxides are damaging compounds involved in the oxidative stress process. A number of studies have demonstrated the close association between health and well-being and the intake of antioxidant-rich foods, including mushrooms [3]. As a wellness related mushroom, Lion's Mane has an abundance of active substances that may support ant-ioxidative roles to reduce ROS-associated health ailments. *

Fatigue can be defined as a situation in which the capacity for work is diminished and the efficiency of accomplishment is reduced, and it can be classified as physical or mental, depending on its cause. Liu et al., 2015 studied the energy supporting properties of polysaccharides extracted from Lion's Mane. This fungus has significant fatigue supporting properties that could be seen by a decrease of blood lactic acid, serum urea nitrogen, and malondialdehyde, as well as an increase in tissue glycogen content and antioxidant enzyme activity [4]. *

The worldwide prevalence of diabetes for all age groups was estimated to be 2.8% in 2000 and it is projected to reach 4.4% in 2030 [5]. The aqueous extract of Lion's Mane may possess hypoglycemic and hypolipidemic suportive properties [6]. Some studies suggest assistance in healthy insuIin levels when food is supplemented with Lion's Mane. Similarly, Hao et al., (2015) studied the protective effects of Lion's Mane on alcohol-induced hepatotoxicity. Lion's Mane supported serum alanine aminotransferase, aspartate aminotransferase, and maleic dialdehyde levels. This fungus had a significant role in supporting hepatic health in relation to alcohol [7] *

Lion's Mane has a significant cell-calming and cell-homeostasis in the management of replication and reproductive abilities effect on primary myeloma cells, human myeloma cell lines, and other cell lines in in vitro tests [8]. Another study discovered that Lion's Mane could provide gastrointestinal health support. Diling et al., (2017) demonstrated that Lion's Mane extract could promote the health of beneficial gut bacteria and support host immunity. The study provided potential clinical evidence on Lion's Mane in the management of bowel health by regulation of gut microbiota and the immune system [9]. The multipurpose biological properties of Lion's Mane have been reported in many brain health studies. Regular administration can may offer mood and anxious thought support by enhancing adult hippocampal neurogenesis [10]. *

Stroke is the 4th leading cause of death and the primary cause of long-term disability worldwide. Ischemic insult produces excessive free radicals, which then causes abnormal endoplasmic reticulum stress signaling that has been linked to apoptosis. These events then induce apoptotic cell death in neurons. A study by Kam-Fai Lee et al., (2014) confirmed the nerve-growth properties of Lion's Mane mycelium, which include the support of neuron health [11]. Another extraordinary study was conducted by Chang et al., (2016) on Lion's Mane and its antiangiogenic potential. The promising results discovered the factor responsible for angiogenesis, proving that Lion's Mane is a potential antiangiogenic supporting agent [12]. *

It has been proven that the dysregulation of nerve growth factor signaling is linked to early stages of neurological diseases. Erinacine A, (the main representative of compounds in Lion's Mane extract) has demonstrated epinephrine-stronger nerve growth factor-inducing activities in in vitro and in vivo tests [13]. In a recent study, it was discovered that a unique polysaccharide fraction from Lion's Mane mycelium designated EP-1 exhibited gastro-health supporting properties [14]. *

Nutritional Value of Lion's Mane Extract

Lion's Mane contains proteins, unsaturated fatty acids, carbohydrates and a variety of trace elements, including phosphorus, sulfur, calcium, magnesium, zinc, iron and copper. All the nutrients serve important roles in the multiple physiological systems of humans, including the nervous, digestive, circulatory and immune systems. *

Suggested Usage / Dosage

The recommended dosage for this extract is 300 mg daily.

Ideal Storage Conditions

Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.

Shelf Life

2 years from Date of Manufacture.

References

  1. Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals. Jiang S, Wang S, Sun Y, Zhang Q Appl Microbiol Biotechnol. 2014 Sep; 98(18):7661-70.
  2. JIANG S, WANG Y, ZHANG X. Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. Experimental and Therapeutic Medicine. 2016;12(1):513-517. doi:10.3892/etm.2016.3279.
  3. Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities. Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF Evid Based Complement Alternat Med. 2012; 2012():464238.
  4. LIU J, DU C, WANG Y, YU Z. Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus. Experimental and Therapeutic Medicine. 2015;9(2):483-487. doi:10.3892/etm.2014.2139.
  5. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Wild S, Roglic G, Green A, Sicree R, King H.Diabetes Care. 2004 May; 27(5):1047-53.
  6. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complementary and Alternative Medicine. 2013;13:253. doi:10.1186/1472-6882-13-253.
  7. Hao L, Xie Y, Wu G, et al. Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evidence-based Complementary and Alternative Medicine : eCAM. 2015;2015:418023. doi:10.1155/2015/418023.
  8. Diling C, Xin Y, Chaoqun Z, et al. Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota. Oncotarget. 2017;8(49):85838-85857. doi:10.18632/oncotarget.20689.
  9. Tangen J-M, Holien T, Mirlashari MR, Misund K, Hetland G. Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan. Biomed Res Int. 2017;2017:2059825. doi:10.1155/2017/2059825.
  10. Ryu S, Kim HG, Kim JY, Kim SY, Cho K-O. Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain. J Med Food. November 2017. doi:10.1089/jmf.2017.4006.
  11. Lee K-F, Chen J-H, Teng C-C, et al. Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death via the Inhibition of iNOS/p38 MAPK and Nitrotyrosine. International Journal of Molecular Sciences. 2014;15(9):15073-15089. doi:10.3390/ijms150915073.
  12. Chang HC, Yang H-L, Pan J-H, et al. Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells. Oxidative Medicine and Cellular Longevity. 2016;2016:8257238. doi:10.1155/2016/8257238.
  13. Mori K., Inatomi S., Ouchi K., Azumi Y., Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother. Res. 2009;23(3):367–372.
  14. Wang M, Kanako N, Zhang Y, Xiao X, Gao Q, Tetsuya K. A unique polysaccharide purified from Hericium erinaceus mycelium prevents oxidative stress induced by H2O2 in human gastric mucosa epithelium cell. Gallyas F, ed. PLoS ONE. 2017;12(7):e0181546. doi:10.1371/journal.pone.0181546.

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