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Saw Palmetto 45% Extract

Natural Cell Production*
Regulates Testosterone Levels*
Boosts Libido*
Supports Urological System*
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Product Information

Serenoa repens, commonly known as Saw Palmetto, is a small, low-growing, dwarf-palm tree, native to North America, particularly Florida.

What is Saw Palmetto Extract?

The American-Indians used Samw Palmetto berries medicinally and as a food source. They were used traditionally for a wide range of health ailments, like lung health, common colds,urinary health, and as a sexual support supplement. The Mayans drank it as a tonic, and the Seminoles used the berries as an expectorant and antiseptic. Since the 1990s, saw palmetto has been one of the top 10 top-selling herbal medicines in the United States [1]. Research suggests that the fatty acids in saw palmetto extracts are responsible for its health benefits. The fatty acid content of saw palmetto supplements has been found to be in percentages ranged from 40.7% to 80.7% [5]. *

How Could Saw Palmetto Extract Support My Health?

The extract of saw palmetto is the herbal extract most frequently used to support a healthy urinary tract and prostate, and evidence from over 35 clinical trials supports the use of standardized saw palmetto extract for this. Use of Saw Palmetto has shown to support optimal peak flow, as well as night time toilet visits [2]. Plant extracts are also widely used for lower urinary tract health in the United States and Europe [3]. In 2007 U.S. survey, 17.7% of adults reported use of a natural product, and 5.1% of users had taken saw palmetto [4] *

A systematic literature review of 11 studies identified saw palmetto supplements as one of five commonly used complementary or alternative medicine modalities by men with prostate health issues (1.9%–24.9%) [6]. Saw palmetto extracts predominantly consist of medium-chain fatty acids (~90%) such as laurate and myristate responsible for its ability to inhibit 5α-reductase [7]. Many studies suggest saw palmetto fatty acids may support healthy cell production and the management of cell mutation. *

Research also suggests Saw Palmetto may support healthy live function, and optimal hair growth in men. *

Bacterial prostatitis is a common condition responsible for about 5-10% of all prostatitis cases. Chronic bacterial prostatitis classified as type II, are less common but is a condition that significantly hampers the quality of life, because not only is it a physical condition but also a psychological distress. Saw palmetto nutritional supplement show potential as a support for chronic bacterial prostatitis, in comparison with antibiotic treatment alone [9]. *

Human gliomas which originate from neural stromal cells are the most common and malignant brain tumor in humans. The glioma has a strong ability in promoting the formation of angiogenesis and microvascular network to provide the tumor with nutrients for the sake of further invasion and metastasis. So, the treatment of antiangiogenesis therapy has become an important method in glioma. It is found that saw palmetto extract is supportive for human glioma through STAT3 signal pathway. Saw palmetto extract may be useful as an adjunctive agent for individuals with glioma and other types in which STAT3 signaling is activated [10]. The results suggest that saw palmetto extract can increase the apoptosis of glioma cells. *

Liver cancer is one of the most prevalent human malignancies all over the world. As the sixth most common cancer, there are 782,000 new cases of liver cancer diagnosed annually and the death rate is increasing annually [11]. Saw Palmetto fatty acid-rich fraction exhibited significant cell mass support on human hepatocellular carcinoma [12]. Hepatocellular carcinoma (HCC) is the major form, accounting for 85% of liver cancer cases. The fraction is an adjuvant targeting cell mass neovascularization with no toxicity or any adverse side effects or weight loss. *

It is suggested that Saw Palmetto Extract has various health mechanisms (eg, inhibition of 5α-reductase, anti-androgenic effects, anti-proliferative effects, cell-calming effects, and anti-edema effects). However, most of these pharmacological effects were observed at relatively high concentrations or large doses of Saw Palmetto Extract. *

Nutritional Value or Phytochemical Content

The extract contains 70–95% free fatty acids like capric, caproic, caprylic, lauric, myristic, oleic, linoleic, linolenic, stearic and palmitic acids with their ethyl esters and glycerides that occur most likely during the extraction process. Further phytosterols like β-sitosterol and β-sitosterol 3-O-D-glucoside, campesterol, and stigmasterol are found with about 0.1% of the total mass of the berries. Other constituents are alcohols, carbohydrates such as mannitol and polysaccharides with galactose and arabinose, triterpenes, aromatic acids like ferulic and vanillic acid, β-carotens, the vitamine E derivates γ-tocopherol and δ-tocopherols, mono-acyl glycerides like 1-monolaurin and 1-monomyristin, and the monoamine tyramine.

Suggest Usage / Dosage

Take 160 - 320mg of our extract daily.

Ideal Storage Conditions

Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.

 

Shelf Life

Two years from date of manufacture.

References

  1. Büchter C, Zhao L, Havermann S, et al. TSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans . Oxidative Medicine and Cellular Longevity. 2015;2015:124357. doi:10.1155/2015/124357
  2. Lin, Longfei; Ni, Boran; Lin, Hongmei; Zhang, Miao; etc. (15 January 2015). "Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: A review". Journal of Ethnopharmacology. 159: 158–183.
  3. Polygonum multiflorum and liver reactions". MHRA. 2006. Archived from the original on 2014-12-05.
  4. Lin, Longfei; Ni, Boran; Lin, Hongmei; Zhang, Miao; etc. (15 January 2015). "Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: A review". Journal of Ethnopharmacology. 159: 158–183.
  5. Beneficial effects of different Polygonum multiflorum Thunb. extracts on memory and hippocampus morphology. Chan YC, Cheng FC, Wang MF J Nutr Sci Vitaminol (Tokyo). 2002 Dec; 48(6):491-7.
  6. Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. Sun FL, Zhang L, Zhang RY, Li L Eur J Pharmacol. 2011 Jun 25; 660(2-3):283-90.
  7. Han M-N, Lu J-M, Zhang G-Y, Yu J, Zhao R-H. Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying. BioMed Research International. 2015;2015:651048. doi:10.1155/2015/651048.
  8. Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells.Steele ML, Truong J, Govindaraghavan S, Ooi L, Sucher NJ, Münch G Neurochem Int. 2013 Apr; 62(5):522-9.
  9. Hexane extract from Polygonum multiflorum attenuates glutamate-induced apoptosis in primary cultured cortical neurons.Jang JY, Kim HN, Kim YR, Choi YW, Choi YH, Lee JH, Shin HK, Choi BTJ Ethnopharmacol. 2013 Jan 9; 145(1):261-8.
  10. Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice. Wang X, Zhao L, Han T, Chen S, Wang JEur J Pharmacol. 2008 Jan 14; 578(2-3):339-48.
  11. Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation. Wang T, Gu J, Wu PF, Wang F, Xiong Z, Yang YJ, Wu WN, Dong LD, Chen JG Free Radic Biol Med. 2009 Aug 1; 47(3):229-40.
  12. Effect of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside on lipoprotein oxidation and proliferation of coronary arterial smooth cells. Liu QL, Xiao JH, Ma R, Ban Y, Wang JL J Asian Nat Prod Res. 2007 Sep-Dec; 9(6-8):689-97.
  13. Stilbene glucoside from Polygonum multiflorum Thunb.: a novel natural inhibitor of advanced glycation end product formation by trapping of methylglyoxal. Lv L, Shao X, Wang L, Huang D, Ho CT, Sang SJ Agric Food Chem. 2010 Feb 24; 58(4):2239-45.
  14. Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity.Sun FL, Zhang L, Zhang RY, Li LEur J Pharmacol. 2011 Jun 25; 660(2-3):283-90.
  15. Bounda G-A, Feng Y. Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds. Pharmacognosy Research. 2015;7(3):225-236. doi:10.4103/0974-8490.157957.
  16. Choi SG, Kim J, Sung ND, Son KH, Cheon HG, Kim KR, et al. Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb. Nat Prod Res. 2007;21:487–93.
  17. Zuo GY, Wang GC, Zhao YB, Xu GL, Hao XY, Han J, et al. Screening of Chinese medicinal plants for inhibition against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) J Ethnopharmacol. 2008;120:287–90.
  18. Cha DS, Jeon H. Anti-inflammatory effect of MeOH extracts of the stem of Polygonum multiflorum in LPS-stimulated mouse peritoneal macrophages. Nat Prod Sci. 2009;15:83–9.
  19. Lin HW, Sun MX, Wang YH, Yang LM, Yang YR, Huang N, et al. Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum. Planta Med. 2010;76:889–
  20. Lin L, Li H, Lin H, et al. A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor. Frontiers in Pharmacology. 2017;8:349. doi:10.3389/fphar.2017.00349.

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