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Biotanica, 5-HTP, Premium Extract

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Biotanica, 5-HTP, Premium Extract

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Supports Optimal Mood.*
Healthy Weight Management.*
Promotes Restful Sleep.*
Healthy Serotonin Levels.*
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Product Description

5-hydroxy tryptamine (5-HTP) is a chemical neurotransmitter obtained from the decarboxylation and hydroxylation of an amino acid (l-tryptophan). It obtained on a commercial basis from the mature seed of African Plant(Griffonia simplicifolia). 5-HTP is obtained from the seed of a plant that is native to West and Central Africa. The woody plant is about 10 feet tall, flanked by green flowers and black pods.

Indigenous people have used this plant for various traditional reasons like the promotion of normal gastro-intestinal functions in people with diarrhea and other psycho-related problems before the advancement in science. 5-HTP has a chemical formula of C11 H12 N2 O3 and a molecular mass of 220, its chemical name is 2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid.[2] The compound has been reported to help promote sleep and other neuro-related functions. Evidence presents that the plant extract can boosts the serotonin level in the body, thereby supporting a healthy body mood.[1].

The extract has also been found to cause some mild side effects like nausea, drowsiness, and reduced libido [4]. The majority of the excellent benefits of 5-HTP lies in the ability to be converted to serotonin. Though the extract has many potential benefits, it is yet to be certified by the FDA due to low-quality clinical studies [3}.  

Product Benefits

Over time there has been a surge in the use of 5-HTP extract for various health reasons. The extract is being sold in various forms. Below are the benefits of 5-HTP

Restful Sleep

American sleep association (ASA) estimates that 50-70 million American adults have a sleep disorder. The 5-HTP extract is a precursor of serotonin and melatonin which are known to improve sleep.5-HTP at a dose of 50mg or less can improve Rapid eye movement(REM) sleep. The depth of REM is dose-dependent.[6]. The packaged extracts are being sold as dietary supplements in various supermarkets at different strengths such as 50mg,150mg,200mg. A combination of 5-HTP with GABA (Amino acid extract) have a significant role in decreasing sleep latency, thereby improving the quality of sleep. [2]

Mood Support

300 million people have been estimated to be depressed worldwide (WHO,2017),this has made people turn to Complementary and alternative Medicine for solution in the US. In a study, 5-HTP extract formulated in an extended-release manner can enhance the mood in people who have been reported to be resistant to depression treatment. The slow-released formulated 5-HTP extract could improve the condition of people that have been diagnosed with Obsessive-compulsive disorder(OCD)[7]. 5-HTP can bring about mood-boosting when used with other neurotransmitters. Regular daily intake of 50-100mg three times daily of the extract could give beneficial mood enhancement if taken in a week [2]. 5-HTP is a natural mood booster and by extension discourage processes that leads to pain.


Head Calming

Migraine occurs in 4% of the adult population worldwide (WHO, headache facts,Migraine2015). Before now, the cause(s) of migraine is yet unknown, but with the advancement in technology,it was reported that a decrease in the level of 5-HTP(serotonin precursor) could lead to migraine attacks amongst other causes[10]. 5-HTP plays a significant role in the reduction of the Migraine. A Davalos, F Titus in a research carried observed that 5-HTP extract produced an improvement in 75% of the patient (migraineur) with minimal side effect by increasing serotonin level in the brain [11]

Joint Aches & Pains

2-8% of the world population suffers from a high level of pain. Serotonin depletion has been implicated to be one of the causes of the pain. The 5-HTP extract has been reported to effectively boosts the serotonin level in the body, consequently supporting the process that leads pain reief[12].

Weight Management

5-HTP through chemical processes produces serotonin which supports the serotonin level in the brain. Serotonin gives a sense of fullness, thereby reducing your appetite. In a research study, it was observed that tryptophan, converted to 5-HTP affects gastric emptying and eating appetite [13]. Currently, there is insufficient evidence, but 5-HTP has been reported to have an anxiolytic effect.

Nutritional Profile
5-HTP may not be obtained directly from food, but one can get tryptophan, which is converted to 5-HTP and then serotonin. Diet rich in tryptophan are: Seeds and nuts, Bananas, Soya beans, Cheese & Fish.

References

1. Shaw KA, Turner J, Del Mar C. Tryptophan and 5‐Hydroxytryptophan for depression. Cochrane Database of Systematic Reviews 2002, Issue 1. Art. No.: CD003198. DOI: 10.1002/14651858.CD003198.         

2. National Center for Biotechnology Information. PubChem Database. 5-Hydroxytryptophan, CID=144, https://pubchem.ncbi.nlm.nih.gov/compound/5-hydroxytryptophan (accessed on July 24, 2020)           

3. Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem. 1994;40(2):288-295.             

4. Bennett, Doug. (2020, July 25). What Is Griffonia Simplicifolia?. sciencing.com. Retrieved from https://sciencing.com/griffonia-simplicifolia-8748120.html.             

5. Vashadze S. (2007). Insomnia, Serotonin and Depression. Georgian medical news, (150), 22–24.          Deborah W. (2020).

6. How Do I Use 5-HTP Insomnia? Wisegeek.com. Retrieved from             : https://www.wisegeek.com/how-do-i-use-5-htp-for-insomnia.htm             

7. Jacobsen JPR, Krystal AD, Krishnan KRR, Caron MG. Adjunctive 5- Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Pre-Clinical Rationale. Trends in Pharmacological Sciences. 2016;37(11):933–944. doi:10.1016/j.tips.2016.09.001.              

8. Hinz M, Stein A, Uncini T. 5-HTP efficacy and contraindications. Neuropsychiatr Dis Treat. 2012;8:323-8. doi:10.2147/NDT.S33259              

9. 5-Hydroxytryptophan (5-HTP). Penn State Hershey: Milton S. Hershey Medical Center. Updated January 1, 2017.                  

10. Horvath, G. A., Selby, K., Poskitt, K., Hyland, K., Waters, P. J., Coulter-Mackie, M., and Stockler-Ipsiroglu, S. G. Hemiplegic migraine, seizures, progressive spastic paraparesis, mood disorder, and coma in siblings with low systemic serotonin. Cephalalgia 2011;31(15):1580-1586.                  

11. Titus, F., Dávalos, A., Alom, J., & Codina, A. (1986). 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. European neurology, 25(5), 327–329. https://doi.org/10.1159/000116030 .                  

12. Clauw D. J. (2014). Fibromyalgia: a clinical review. JAMA, 311(15), 1547–1555. https://doi.org/10.1001/jama.2014.3266.                  

13. Sauer, H., Mack, I., Kohler, S., Siegle, S., Rieber, N., Zipfel, S., Otto, B., Ritze, Y., Bischoff, S. C., & Enck, P. (2014). The effects of 5-hydroxytryptophan in combination with different Fatty acids on gastrointestinal functions: a pilot experiment. Gastroenterology research and practice, 2014, 424503. https://doi.org/10.1155/2014/424503

Delivery Methods

We ship worldwide using NZ Post Priority and Express Tracked mail service. All orders placed with us are tracked so that you can find your order at any time, once it has been dispatched.

Delivery Time
Most orders are shipped by 4 PM within two business days. If for some reason we cannot ship your order by 4 PM within two business days, we will email you to let you know within 48 hours.

NZ Delivery Time
All New Zealand orders are tracked. Please allow for 2 business days for processing and packaging, with 3 - 5 business days to arrive.

USA Delivery Time
We use tracked Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent

Canada Delivery Time
We use tracked Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent

Australia Delivery Time
We use tracked Priority shipping which may take up to 6 - 8 days. Please allow for 2 business days for processing and packaging before your order is sent.

All Other International Countries Delivery Time
We use Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent.
Returns With Us Are Easy

Biotanica® maintains a total customer satisfaction guarantee on all Biotanica® auto-delivery products. If you, the customer, are unhappy with the product for any reason, you can return the unused item(s) for a full refund of the purchase price minus delivery and handling. To obtain your refund, you must email us at: returns@BiotanicaHealth.com with your order number so we can process your refund.

Your order number can easily be found next to your name on grey package it arrived in.

To receive your refund, your return must be received at our delivery facility within 30 days of purchase. You pay for return delivery.

Please send your package to:

Biotanica® Health
P O Box 147200
Ponsonby
Auckland
1011
New Zealand

We will not accept or issue a refund for any packages marked return to sender or refused. If you return a package, we recommend that you get proof of shipment. Upon receipt of your returned product, a refund will be issued to your credit card.

After the delivery department receives your return, it generally takes 3 - 5 business days or less to process your refund. Once a return is processed, it can take up to one billing cycle for the refund to be posted to your account, depending on your financial banking institution.

Here are 5 more great reasons to buy from us:

You get a full 30 days to return your item to us. If it's not right for you, you've changed your mind or for no reason whatsoever simply send it back to us and we'll cheerfully refund your order less any applicable bank and service fees.

Returns are easy, simply click here for our returns policy. We'll get you a replacement or refund in a snap!

In the unlikely event that you find your item cheaper at another online store, just let us know and we'll beat the competitor's pricing hands-down.

We insist that you love everything you buy from us. If you're unhappy for any reason whatsoever, just let us know and we'll bend over backwards to make things right again.

Ordering from Biotanica® is 100% safe and secure so you can rest easy. Your personal details are never shared, sold or rented to anyone.

Product Description

5-hydroxy tryptamine (5-HTP) is a chemical neurotransmitter obtained from the decarboxylation and hydroxylation of an amino acid (l-tryptophan). It obtained on a commercial basis from the mature seed of African Plant(Griffonia simplicifolia). 5-HTP is obtained from the seed of a plant that is native to West and Central Africa. The woody plant is about 10 feet tall, flanked by green flowers and black pods.

Indigenous people have used this plant for various traditional reasons like the promotion of normal gastro-intestinal functions in people with diarrhea and other psycho-related problems before the advancement in science. 5-HTP has a chemical formula of C11 H12 N2 O3 and a molecular mass of 220, its chemical name is 2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid.[2] The compound has been reported to help promote sleep and other neuro-related functions. Evidence presents that the plant extract can boosts the serotonin level in the body, thereby supporting a healthy body mood.[1].

The extract has also been found to cause some mild side effects like nausea, drowsiness, and reduced libido [4]. The majority of the excellent benefits of 5-HTP lies in the ability to be converted to serotonin. Though the extract has many potential benefits, it is yet to be certified by the FDA due to low-quality clinical studies [3}.  

Product Benefits

Over time there has been a surge in the use of 5-HTP extract for various health reasons. The extract is being sold in various forms. Below are the benefits of 5-HTP

Restful Sleep

American sleep association (ASA) estimates that 50-70 million American adults have a sleep disorder. The 5-HTP extract is a precursor of serotonin and melatonin which are known to improve sleep.5-HTP at a dose of 50mg or less can improve Rapid eye movement(REM) sleep. The depth of REM is dose-dependent.[6]. The packaged extracts are being sold as dietary supplements in various supermarkets at different strengths such as 50mg,150mg,200mg. A combination of 5-HTP with GABA (Amino acid extract) have a significant role in decreasing sleep latency, thereby improving the quality of sleep. [2]

Mood Support

300 million people have been estimated to be depressed worldwide (WHO,2017),this has made people turn to Complementary and alternative Medicine for solution in the US. In a study, 5-HTP extract formulated in an extended-release manner can enhance the mood in people who have been reported to be resistant to depression treatment. The slow-released formulated 5-HTP extract could improve the condition of people that have been diagnosed with Obsessive-compulsive disorder(OCD)[7]. 5-HTP can bring about mood-boosting when used with other neurotransmitters. Regular daily intake of 50-100mg three times daily of the extract could give beneficial mood enhancement if taken in a week [2]. 5-HTP is a natural mood booster and by extension discourage processes that leads to pain.


Head Calming

Migraine occurs in 4% of the adult population worldwide (WHO, headache facts,Migraine2015). Before now, the cause(s) of migraine is yet unknown, but with the advancement in technology,it was reported that a decrease in the level of 5-HTP(serotonin precursor) could lead to migraine attacks amongst other causes[10]. 5-HTP plays a significant role in the reduction of the Migraine. A Davalos, F Titus in a research carried observed that 5-HTP extract produced an improvement in 75% of the patient (migraineur) with minimal side effect by increasing serotonin level in the brain [11]

Joint Aches & Pains

2-8% of the world population suffers from a high level of pain. Serotonin depletion has been implicated to be one of the causes of the pain. The 5-HTP extract has been reported to effectively boosts the serotonin level in the body, consequently supporting the process that leads pain reief[12].

Weight Management

5-HTP through chemical processes produces serotonin which supports the serotonin level in the brain. Serotonin gives a sense of fullness, thereby reducing your appetite. In a research study, it was observed that tryptophan, converted to 5-HTP affects gastric emptying and eating appetite [13]. Currently, there is insufficient evidence, but 5-HTP has been reported to have an anxiolytic effect.

Nutritional Profile
5-HTP may not be obtained directly from food, but one can get tryptophan, which is converted to 5-HTP and then serotonin. Diet rich in tryptophan are: Seeds and nuts, Bananas, Soya beans, Cheese & Fish.

References

1. Shaw KA, Turner J, Del Mar C. Tryptophan and 5‐Hydroxytryptophan for depression. Cochrane Database of Systematic Reviews 2002, Issue 1. Art. No.: CD003198. DOI: 10.1002/14651858.CD003198.         

2. National Center for Biotechnology Information. PubChem Database. 5-Hydroxytryptophan, CID=144, https://pubchem.ncbi.nlm.nih.gov/compound/5-hydroxytryptophan (accessed on July 24, 2020)           

3. Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem. 1994;40(2):288-295.             

4. Bennett, Doug. (2020, July 25). What Is Griffonia Simplicifolia?. sciencing.com. Retrieved from https://sciencing.com/griffonia-simplicifolia-8748120.html.             

5. Vashadze S. (2007). Insomnia, Serotonin and Depression. Georgian medical news, (150), 22–24.          Deborah W. (2020).

6. How Do I Use 5-HTP Insomnia? Wisegeek.com. Retrieved from             : https://www.wisegeek.com/how-do-i-use-5-htp-for-insomnia.htm             

7. Jacobsen JPR, Krystal AD, Krishnan KRR, Caron MG. Adjunctive 5- Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Pre-Clinical Rationale. Trends in Pharmacological Sciences. 2016;37(11):933–944. doi:10.1016/j.tips.2016.09.001.              

8. Hinz M, Stein A, Uncini T. 5-HTP efficacy and contraindications. Neuropsychiatr Dis Treat. 2012;8:323-8. doi:10.2147/NDT.S33259              

9. 5-Hydroxytryptophan (5-HTP). Penn State Hershey: Milton S. Hershey Medical Center. Updated January 1, 2017.                  

10. Horvath, G. A., Selby, K., Poskitt, K., Hyland, K., Waters, P. J., Coulter-Mackie, M., and Stockler-Ipsiroglu, S. G. Hemiplegic migraine, seizures, progressive spastic paraparesis, mood disorder, and coma in siblings with low systemic serotonin. Cephalalgia 2011;31(15):1580-1586.                  

11. Titus, F., Dávalos, A., Alom, J., & Codina, A. (1986). 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. European neurology, 25(5), 327–329. https://doi.org/10.1159/000116030 .                  

12. Clauw D. J. (2014). Fibromyalgia: a clinical review. JAMA, 311(15), 1547–1555. https://doi.org/10.1001/jama.2014.3266.                  

13. Sauer, H., Mack, I., Kohler, S., Siegle, S., Rieber, N., Zipfel, S., Otto, B., Ritze, Y., Bischoff, S. C., & Enck, P. (2014). The effects of 5-hydroxytryptophan in combination with different Fatty acids on gastrointestinal functions: a pilot experiment. Gastroenterology research and practice, 2014, 424503. https://doi.org/10.1155/2014/424503

Delivery Methods

We ship worldwide using NZ Post Priority and Express Tracked mail service. All orders placed with us are tracked so that you can find your order at any time, once it has been dispatched.

Delivery Time
Most orders are shipped by 4 PM within two business days. If for some reason we cannot ship your order by 4 PM within two business days, we will email you to let you know within 48 hours.

NZ Delivery Time
All New Zealand orders are tracked. Please allow for 2 business days for processing and packaging, with 3 - 5 business days to arrive.

USA Delivery Time
We use tracked Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent

Canada Delivery Time
We use tracked Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent

Australia Delivery Time
We use tracked Priority shipping which may take up to 6 - 8 days. Please allow for 2 business days for processing and packaging before your order is sent.

All Other International Countries Delivery Time
We use Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent.
Returns With Us Are Easy

Biotanica® maintains a total customer satisfaction guarantee on all Biotanica® auto-delivery products. If you, the customer, are unhappy with the product for any reason, you can return the unused item(s) for a full refund of the purchase price minus delivery and handling. To obtain your refund, you must email us at: returns@BiotanicaHealth.com with your order number so we can process your refund.

Your order number can easily be found next to your name on grey package it arrived in.

To receive your refund, your return must be received at our delivery facility within 30 days of purchase. You pay for return delivery.

Please send your package to:

Biotanica® Health
P O Box 147200
Ponsonby
Auckland
1011
New Zealand

We will not accept or issue a refund for any packages marked return to sender or refused. If you return a package, we recommend that you get proof of shipment. Upon receipt of your returned product, a refund will be issued to your credit card.

After the delivery department receives your return, it generally takes 3 - 5 business days or less to process your refund. Once a return is processed, it can take up to one billing cycle for the refund to be posted to your account, depending on your financial banking institution.

Here are 5 more great reasons to buy from us:

You get a full 30 days to return your item to us. If it's not right for you, you've changed your mind or for no reason whatsoever simply send it back to us and we'll cheerfully refund your order less any applicable bank and service fees.

Returns are easy, simply click here for our returns policy. We'll get you a replacement or refund in a snap!

In the unlikely event that you find your item cheaper at another online store, just let us know and we'll beat the competitor's pricing hands-down.

We insist that you love everything you buy from us. If you're unhappy for any reason whatsoever, just let us know and we'll bend over backwards to make things right again.

Ordering from Biotanica® is 100% safe and secure so you can rest easy. Your personal details are never shared, sold or rented to anyone.

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