Biotanica, Frankincense, Boswellia Premium Organic Essential Oil

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Biotanica, Frankincense, Boswellia Premium Organic Essential Oil

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Boosts Immune System*
Supports Oral Health*
Promotes Healthy Digestion*
Stress & Mood Support*

$44.95

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Oleogum resins from Boswellia species is known as frankincense.

What is Frankincense Essential Oil?

Frankincense is popularly known as Indian olibanum, salai guggal, loban, or kundur. The word frankincense is derived from the ancient French name meaning "pure incense". In recent years, it has been important in the preparation of cosmetics and perfumes. Frankincense has been used as a major ingredient in Ayurvedic and Chinese medicine to support a variety of health-related benefits[1]. One of the remarkable properties of frankincense is in rest and sleep support [2]. In relaxation therapy, frankincense oil is either inhaled or diffused in vaporizer which works like a relaxant and may help to support a feeling of intellectual peace, relaxation, and satisfaction, and which may help support symptoms of anxiousness, anger and stress. Frankincense may be among mankind's oldest remedies [23], and in the contemporary era, it is still used extensively in regions ranging from North Africa to China. Much attention has been focused on the beneficial effects of frankincense as a wellness component of health benefits targeting respiratory health, cell homeostasis, bowel movements, joint health, bone health and brain health [21]. It is also used in the support of a healthy nervous system and immune support [22]. *

How Could Frankincense Essential Oil Improve My Health?

Frankincense essential oil prepared from hydrodistillation of Boswellia species gum resins has been considered throughout the ages to have a wealth of health supporting properties. The resins of Boswellia carteri and Boswellia serrata have been used in joint support and cell homeostasis [3] [4]. The flammatory supporting activity has been attributed to the resin's ability to support healthy immune cytokines production [5] and leukocyte infiltration [6].*
Frankincense extract also exhibits bacterial and fungal support agents [7].*
Frankincense essential oil from gum resins might possess healthy cell reproduction activities, based on their anti-proliferative and pro-apoptotic activities in rat astrocytoma cell lines [9] and in human leukemia cell lines [10], as well as their carcinogenic suppporting activity in chemically induced mouse skin health [11]. Clinically, extract from the resin supports healthy peritumoral edema in [12] and the management of cell mass growth support in breast health [13].*
11-keto-β-boswellic acid is the most suitable cell mass supporting and cell homeostasis [20] component of the frankincense resin oil. It supports endotoxin/galactosamine-induced health in an animal model [14] and shown to possess health cell division activities through their cytostatic and apoptotic effects in multiple cell lines [15-19]. Epstein–Barr virus, a human herpesvirus is susceptible to triterpenoids from resins. The report says the resin has an antigen activation and, thus, as potential cell mass growth activities [24]. A total of 53 compounds and 47 components that have been reported to be among the triterpenoid resinous metabolites from the frankincense resin oil [25] with various health supporting activities.*
Atherosclerosis is the building up of plaque inside the blood vessels, causing hardening of the arteries. It is the major cause of coronary heart disease and has been found to be linked to cells out of homeostasis. Data clearly indicates that 3-O-acetyl-11-keto-β-boswellic acid (AKBA - boswellic acid of resins) supports healthy cell homeostasis through the inhibition of nuclear transcription factor-kappa B (NF-κB) [28].*
Frankincense is used by the Jordanian population as an aphrodisiac and a fertility promoting agent [29]. It may act on the pituitary gland and increase the main hormones of spermatogenesis. A significant increase in the sperm motility of cauda epididymis was observed in the treatment group, which may be due to the effect of frankincense on the enzymes of oxidative phosphorylation [29].*
Frankincense resins are believed to support healthy learning and memory on consumption, and it has been used by the elderly for memory enhancement and by pregnant women to enhance the memory and intelligence of their offspring [30].*
The essential oil isolated from the oleogum resin of Boswellia carterii has been found to have microbial supporting activities for gram-positive and gram-negative [31]. Type I diabetes is an autoimmune disease in which a chronic inflammatory process finally causes beta-cell death and insuIin deficiency. Extracts from the gum resin of B. serrata have been shown to support blood glucose balance. The study shows that Boswellia extract has blood glucose suppporting effects and could support a healthy liver and kidneys [32, 33].*

Active Constituents

Frankincense is reported to contain 60-85% resins (mixtures of terpenes), 6-30% gums (a mixture of polysaccharides), and 5-9% essential oil. Resin portion is composed of pentacyclic triterpenes, in which boswellic acid is the active functional group. Gum portion consists of pentose and hexose sugars with some oxidizing and digestive enzymes. The essential oil is a mixture of monoterpenes, diterpenes, and sesquiterpenes. Resinous part rich in Monoterpenes (α-thujone); diterpenes [macrocyclic diterpenoids such as incensole, incensole oxide, iso-incensole oxide, a diterpene alcohol (serratol)]; triterpenes (such as α- and β-amyrins); pentacyclic triterpenic acids (boswellic acids); and tetracyclic triterpenic acids (tirucall-8,24-dien-21-oic acids)-amyrins); pentacyclic triterpenic acids (boswellic acids); and tetracyclic triterpenic acids (tirucall-8,24-dien-21-oic acids). The four major boswellic acids (pentacyclic triterpenic acids) found in frankincense are: β-boswellic acid (BA), acetyl-β-boswellic acid (ABA), 11-keto-β-boswellic acid (KBA), and 3-O-acetyl-11-keto-β-boswellic acid (AKBA), which have been shown to be responsible for the inhibition of pro-inflammatory enzymes and AKBA is the most potent one.

Suggest Usage / Dosage

Internal Use - 100% pure therapeutic grade essential oil is used for inhaling or vaporizer. Boswellia resin is relatively safe in rat up to the dose of 500 mg/kg B.wt [26]

Topical Use - 4 drops directly to the desired area.

Ideal Storage Conditions

Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.

Shelf Life

Two years from date of manufacture.

References

Ni, Xiao et al. “Frankincense Essential Oil Prepared from Hydrodistillation of Boswellia Sacra Gum Resins Induces Human Pancreatic Cancer Cell Death in Cultures and in a Xenograft Murine Model.” BMC Complementary and Alternative Medicine 12 (2012): 253. PMC. Web. 23 Jan. 2018.
Shanghai Scientific and Technologic Press. Dictionary of Chinese Traditional Medicines. Tokyo, Japan: Shogakkan; 1985
Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri. Banno N, Akihisa T, Yasukawa K, Tokuda H, Tabata K, Nakamura Y, Nishimura R, Kimura Y, Suzuki T J Ethnopharmacol. 2006 Sep 19; 107(2):249-53.
Review article: complementary and alternative therapies for inflammatory bowel disease.Langmead L, Rampton DS Aliment Pharmacol Ther. 2006 Feb 1; 23(3):341-9.
Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro. Chevrier MR, Ryan AE, Lee DY, Zhongze M, Wu-Yan Z, Via CS Clin Diagn Lab Immunol. 2005 May; 12(5):575-80.
Effect of salai guggal ex-Boswellia serrata on cellular and humoral immune responses and leucocyte migration. Sharma ML, Khajuria A, Kaul A, Singh S, Singh GB, Atal CK Agents Actions. 1988 Jun; 24(1-2):161-4.
Screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance. Weckesser S, Engel K, Simon-Haarhaus B, Wittmer A, Pelz K, Schempp CM Phytomedicine. 2007 Aug; 14(7-8):508-16.
Boswellic acids inhibit glioma growth: a new treatment option?Winking M, Sarikaya S, Rahmanian A, Jödicke A, Böker DKJ Neurooncol. 2000; 46(2):97-103.
Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro. Hostanska K, Daum G, Saller R Anticancer Res. 2002 Sep-Oct; 22(5):2853-62.
Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid. Huang MT, Badmaev V, Ding Y, Liu Y, Xie JG, Ho CT Biofactors. 2000; 13(1-4):225-30.
Boswellic acids inhibit glioma growth: a new treatment option? Winking M, Sarikaya S, Rahmanian A, Jödicke A, Böker DK J Neurooncol. 2000; 46(2):97-103.
A lipoxygenase inhibitor in breast cancer brain metastases. Flavin DF J Neurooncol. 2007 Mar; 82(1):91-3.
Protection by boswellic acids against galactosamine/endotoxin-induced hepatitis in mice. Safayhi H, Mack T, Ammon HP Biochem Pharmacol. 1991 May 15; 41(10):1536-7.
Park YS, Lee JH, Bondar J, Harwalkar JA, Safayhi H, Golubic M. Cytotoxic action of acetyl-11-keto-β-boswellic acid (AKBA) on meningioma cells. Planta Medica. 2002;68:397–401. doi: 10.1055/s-2002-32090. [PubMed] [Cross Ref]
Shao Y, Ho CT, Chin CK, Badmaev V, Ma W, Huang MT. Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture. Planta Medica. 1998;64:328–331. doi: 10.1055/s-2006-957444. [PubMed] [Cross Ref]
Liu JJ, Nilsson A, Oredsson S, Badmaev V, Duan RD. Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway. Int J Mol Med. 2002;10:501–505. [PubMed]
Zhao W, Entschladen F, Liu H, Niggemann B, Fang Q, Zaenker KS, Han R. Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells. Cancer Detec Prev. 2003;27:67–75. doi: 10.1016/S0361-090X(02)00170-8. [PubMed] [Cross Ref]
Liu JJ, Nilsson A, Oredsson S, Badmaev V, Zhao WZ, Duan RD. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis. 2002;23:2087–2093. doi: 10.1093/carcin/23.12.2087. [PubMed] [Cross Ref]
Frank, Mark Barton et al. “Frankincense Oil Derived from Boswellia Carteri induces Tumor Cell Specific Cytotoxicity.” BMC Complementary and Alternative Medicine 9 (2009): 6. PMC. Web. 23 Jan. 2018.
Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Abdel-Tawab M, Werz O, Schubert-Zsilavecz M Clin Pharmacokinet. 2011 Jun; 50(6):349-69.
Bioactive constituents from Boswellia papyrifera. Atta-ur-Rahman, Naz H, Fadimatou, Makhmoor T, Yasin A, Fatima N, Ngounou FN, Kimbu SF, Sondengam BL, Choudhary MI J Nat Prod. 2005 Feb; 68(2):189-93.
Tadesse W, Desalegn G, Alia R. Natural gum and resin bearing species of Ethiopia and their potential applications. Investigación agraria. Sistemas y recursos forestales. 2007;16:211–221.
Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri.Akihisa T, Tabata K, Banno N, Tokuda H, Nishimura R, Nakamura Y, Kimura Y, Yasukawa K, Suzuki TBiol Pharm Bull. 2006 Sep; 29(9):1976-9.
Zhang, Yuxin et al. “Triterpenoid Resinous Metabolites from the Genus Boswellia: Pharmacological Activities and Potential Species-Identifying Properties.” Chemistry Central Journal 7 (2013): 153. PMC. Web. 23 Jan. 2018.
A-90 Day Gavage Safety Assessment of Boswellia serrata in Rats. Singh P, Chacko KM, Aggarwal ML, Bhat B, Khandal RK, Sultana S, Kuruvilla BT Toxicol Int. 2012 Sep; 19(3):273-8.
Sontakke S, Thawani V, Pimpalkhute S, Kabra P, Babhulkar S, Hingorani L. Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to vald**oxib in osteoarthritis of knee. Indian J Pharmacol. 2007;39:27. doi: 10.4103/0253-7613.30759
Cuaz-Perolin C, Billiet L, Bauge E, Copin C, Scott-Algara D, Genze F, et al. Antiinflammatory and antiatherogenic effects of the NF-kB inhibitor Acetyl-11-keto-B-Boswellic acid in LPS-challenged ApoE-/- Mice. Arterioscler Thromb Vasc Biol. 2008;28:272–7.
Nusier MK, Bataineh HN, Bataineh ZM, Daradka HM. Effect of frankincense (Boswellia thurifera) on reproductive system in adult male rat. J Health Sci. 2007;53:365–70.
Sharifabad MH, Esfandiari E, Alaei H. Effects of frankincense aqueous extract during gestational period on increasing power of learning and memory in adult offsprings. J Isfahan Med Sch. 2004;21:16–20.
Rahimi R, Shams-Ardekani MR, Abdollahi M. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol. 2010;16:4504–14
Shehata AM, Quintanilla-Fend L, Bettio S, Singh CB, Ammon HP. Prevention of Multiple Low-dose Streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia Serrata (BE) Phytomedicine. 2011;18:1037–44. [PubMed]
Ahmadpour F, Namjoyan F, Azemi M, Khodayar M, Darvish Padok A, Panahi M. Antioxidant capacity and anti-diabetic effect of Boswellia Serrata aqueous extract in female diabetic rats and the possible histological changes in the liver and kidney. Res Pharm Sci. 2012;7:17

Product Information

Oleogum resins from Boswellia species is known as frankincense.

What is Frankincense Essential Oil?

How Could Frankincense Essential Oil Improve My Health?

Frankincense essential oil prepared from hydrodistillation of Boswellia species gum resins has been considered throughout the ages to have a wealth of health supporting properties. The resins of Boswellia carteri and Boswellia serrata have been used in joint support and cell homeostasis [3] [4]. The flammatory supporting activity has been attributed to the resin's ability to support healthy immune cytokines production [5] and leukocyte infiltration [6].*
Frankincense extract also exhibits bacterial and fungal support agents [7].*
Frankincense essential oil from gum resins might possess healthy cell reproduction activities, based on their anti-proliferative and pro-apoptotic activities in rat astrocytoma cell lines [9] and in human leukemia cell lines [10], as well as their carcinogenic suppporting activity in chemically induced mouse skin health [11]. Clinically, extract from the resin supports healthy peritumoral edema in [12] and the management of cell mass growth support in breast health [13].*
11-keto-β-boswellic acid is the most suitable cell mass supporting and cell homeostasis [20] component of the frankincense resin oil. It supports endotoxin/galactosamine-induced health in an animal model [14] and shown to possess health cell division activities through their cytostatic and apoptotic effects in multiple cell lines [15-19]. Epstein–Barr virus, a human herpesvirus is susceptible to triterpenoids from resins. The report says the resin has an antigen activation and, thus, as potential cell mass growth activities [24]. A total of 53 compounds and 47 components that have been reported to be among the triterpenoid resinous metabolites from the frankincense resin oil [25] with various health supporting activities.*
Atherosclerosis is the building up of plaque inside the blood vessels, causing hardening of the arteries. It is the major cause of coronary heart disease and has been found to be linked to cells out of homeostasis. Data clearly indicates that 3-O-acetyl-11-keto-β-boswellic acid (AKBA - boswellic acid of resins) supports healthy cell homeostasis through the inhibition of nuclear transcription factor-kappa B (NF-κB) [28].*
Frankincense is used by the Jordanian population as an aphrodisiac and a fertility promoting agent [29]. It may act on the pituitary gland and increase the main hormones of spermatogenesis. A significant increase in the sperm motility of cauda epididymis was observed in the treatment group, which may be due to the effect of frankincense on the enzymes of oxidative phosphorylation [29].*
Frankincense resins are believed to support healthy learning and memory on consumption, and it has been used by the elderly for memory enhancement and by pregnant women to enhance the memory and intelligence of their offspring [30].*
The essential oil isolated from the oleogum resin of Boswellia carterii has been found to have microbial supporting activities for gram-positive and gram-negative [31]. Type I diabetes is an autoimmune disease in which a chronic inflammatory process finally causes beta-cell death and insuIin deficiency. Extracts from the gum resin of B. serrata have been shown to support blood glucose balance. The study shows that Boswellia extract has blood glucose suppporting effects and could support a healthy liver and kidneys [32, 33].*

Active Constituents

Suggest Usage / Dosage

Ideal Storage Conditions

Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.

Shelf Life

Two years from date of manufacture.

References

Ni, Xiao et al. “Frankincense Essential Oil Prepared from Hydrodistillation of Boswellia Sacra Gum Resins Induces Human Pancreatic Cancer Cell Death in Cultures and in a Xenograft Murine Model.” BMC Complementary and Alternative Medicine 12 (2012): 253. PMC. Web. 23 Jan. 2018.
Shanghai Scientific and Technologic Press. Dictionary of Chinese Traditional Medicines. Tokyo, Japan: Shogakkan; 1985
Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri. Banno N, Akihisa T, Yasukawa K, Tokuda H, Tabata K, Nakamura Y, Nishimura R, Kimura Y, Suzuki T J Ethnopharmacol. 2006 Sep 19; 107(2):249-53.
Review article: complementary and alternative therapies for inflammatory bowel disease.Langmead L, Rampton DS Aliment Pharmacol Ther. 2006 Feb 1; 23(3):341-9.
Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro. Chevrier MR, Ryan AE, Lee DY, Zhongze M, Wu-Yan Z, Via CS Clin Diagn Lab Immunol. 2005 May; 12(5):575-80.
Effect of salai guggal ex-Boswellia serrata on cellular and humoral immune responses and leucocyte migration. Sharma ML, Khajuria A, Kaul A, Singh S, Singh GB, Atal CK Agents Actions. 1988 Jun; 24(1-2):161-4.
Screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance. Weckesser S, Engel K, Simon-Haarhaus B, Wittmer A, Pelz K, Schempp CM Phytomedicine. 2007 Aug; 14(7-8):508-16.
Boswellic acids inhibit glioma growth: a new treatment option?Winking M, Sarikaya S, Rahmanian A, Jödicke A, Böker DKJ Neurooncol. 2000; 46(2):97-103.
Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro. Hostanska K, Daum G, Saller R Anticancer Res. 2002 Sep-Oct; 22(5):2853-62.
Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid. Huang MT, Badmaev V, Ding Y, Liu Y, Xie JG, Ho CT Biofactors. 2000; 13(1-4):225-30.
Boswellic acids inhibit glioma growth: a new treatment option? Winking M, Sarikaya S, Rahmanian A, Jödicke A, Böker DK J Neurooncol. 2000; 46(2):97-103.
A lipoxygenase inhibitor in breast cancer brain metastases. Flavin DF J Neurooncol. 2007 Mar; 82(1):91-3.
Protection by boswellic acids against galactosamine/endotoxin-induced hepatitis in mice. Safayhi H, Mack T, Ammon HP Biochem Pharmacol. 1991 May 15; 41(10):1536-7.
Park YS, Lee JH, Bondar J, Harwalkar JA, Safayhi H, Golubic M. Cytotoxic action of acetyl-11-keto-β-boswellic acid (AKBA) on meningioma cells. Planta Medica. 2002;68:397–401. doi: 10.1055/s-2002-32090. [PubMed] [Cross Ref]
Shao Y, Ho CT, Chin CK, Badmaev V, Ma W, Huang MT. Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture. Planta Medica. 1998;64:328–331. doi: 10.1055/s-2006-957444. [PubMed] [Cross Ref]
Liu JJ, Nilsson A, Oredsson S, Badmaev V, Duan RD. Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway. Int J Mol Med. 2002;10:501–505. [PubMed]
Zhao W, Entschladen F, Liu H, Niggemann B, Fang Q, Zaenker KS, Han R. Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells. Cancer Detec Prev. 2003;27:67–75. doi: 10.1016/S0361-090X(02)00170-8. [PubMed] [Cross Ref]
Liu JJ, Nilsson A, Oredsson S, Badmaev V, Zhao WZ, Duan RD. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis. 2002;23:2087–2093. doi: 10.1093/carcin/23.12.2087. [PubMed] [Cross Ref]
Frank, Mark Barton et al. “Frankincense Oil Derived from Boswellia Carteri induces Tumor Cell Specific Cytotoxicity.” BMC Complementary and Alternative Medicine 9 (2009): 6. PMC. Web. 23 Jan. 2018.
Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Abdel-Tawab M, Werz O, Schubert-Zsilavecz M Clin Pharmacokinet. 2011 Jun; 50(6):349-69.
Bioactive constituents from Boswellia papyrifera. Atta-ur-Rahman, Naz H, Fadimatou, Makhmoor T, Yasin A, Fatima N, Ngounou FN, Kimbu SF, Sondengam BL, Choudhary MI J Nat Prod. 2005 Feb; 68(2):189-93.
Tadesse W, Desalegn G, Alia R. Natural gum and resin bearing species of Ethiopia and their potential applications. Investigación agraria. Sistemas y recursos forestales. 2007;16:211–221.
Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri.Akihisa T, Tabata K, Banno N, Tokuda H, Nishimura R, Nakamura Y, Kimura Y, Yasukawa K, Suzuki TBiol Pharm Bull. 2006 Sep; 29(9):1976-9.
Zhang, Yuxin et al. “Triterpenoid Resinous Metabolites from the Genus Boswellia: Pharmacological Activities and Potential Species-Identifying Properties.” Chemistry Central Journal 7 (2013): 153. PMC. Web. 23 Jan. 2018.
A-90 Day Gavage Safety Assessment of Boswellia serrata in Rats. Singh P, Chacko KM, Aggarwal ML, Bhat B, Khandal RK, Sultana S, Kuruvilla BT Toxicol Int. 2012 Sep; 19(3):273-8.
Sontakke S, Thawani V, Pimpalkhute S, Kabra P, Babhulkar S, Hingorani L. Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to vald**oxib in osteoarthritis of knee. Indian J Pharmacol. 2007;39:27. doi: 10.4103/0253-7613.30759
Cuaz-Perolin C, Billiet L, Bauge E, Copin C, Scott-Algara D, Genze F, et al. Antiinflammatory and antiatherogenic effects of the NF-kB inhibitor Acetyl-11-keto-B-Boswellic acid in LPS-challenged ApoE-/- Mice. Arterioscler Thromb Vasc Biol. 2008;28:272–7.
Nusier MK, Bataineh HN, Bataineh ZM, Daradka HM. Effect of frankincense (Boswellia thurifera) on reproductive system in adult male rat. J Health Sci. 2007;53:365–70.
Sharifabad MH, Esfandiari E, Alaei H. Effects of frankincense aqueous extract during gestational period on increasing power of learning and memory in adult offsprings. J Isfahan Med Sch. 2004;21:16–20.
Rahimi R, Shams-Ardekani MR, Abdollahi M. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol. 2010;16:4504–14
Shehata AM, Quintanilla-Fend L, Bettio S, Singh CB, Ammon HP. Prevention of Multiple Low-dose Streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia Serrata (BE) Phytomedicine. 2011;18:1037–44. [PubMed]
Ahmadpour F, Namjoyan F, Azemi M, Khodayar M, Darvish Padok A, Panahi M. Antioxidant capacity and anti-diabetic effect of Boswellia Serrata aqueous extract in female diabetic rats and the possible histological changes in the liver and kidney. Res Pharm Sci. 2012;7:17

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Oleogum resins from Boswellia species is known as frankincense.

What is Frankincense Essential Oil?

How Could Frankincense Essential Oil Improve My Health?

Frankincense essential oil prepared from hydrodistillation of Boswellia species gum resins has been considered throughout the ages to have a wealth of health supporting properties. The resins of Boswellia carteri and Boswellia serrata have been used in joint support and cell homeostasis [3] [4]. The flammatory supporting activity has been attributed to the resin's ability to support healthy immune cytokines production [5] and leukocyte infiltration [6].*
Frankincense extract also exhibits bacterial and fungal support agents [7].*
Frankincense essential oil from gum resins might possess healthy cell reproduction activities, based on their anti-proliferative and pro-apoptotic activities in rat astrocytoma cell lines [9] and in human leukemia cell lines [10], as well as their carcinogenic suppporting activity in chemically induced mouse skin health [11]. Clinically, extract from the resin supports healthy peritumoral edema in [12] and the management of cell mass growth support in breast health [13].*
11-keto-β-boswellic acid is the most suitable cell mass supporting and cell homeostasis [20] component of the frankincense resin oil. It supports endotoxin/galactosamine-induced health in an animal model [14] and shown to possess health cell division activities through their cytostatic and apoptotic effects in multiple cell lines [15-19]. Epstein–Barr virus, a human herpesvirus is susceptible to triterpenoids from resins. The report says the resin has an antigen activation and, thus, as potential cell mass growth activities [24]. A total of 53 compounds and 47 components that have been reported to be among the triterpenoid resinous metabolites from the frankincense resin oil [25] with various health supporting activities.*
Atherosclerosis is the building up of plaque inside the blood vessels, causing hardening of the arteries. It is the major cause of coronary heart disease and has been found to be linked to cells out of homeostasis. Data clearly indicates that 3-O-acetyl-11-keto-β-boswellic acid (AKBA - boswellic acid of resins) supports healthy cell homeostasis through the inhibition of nuclear transcription factor-kappa B (NF-κB) [28].*
Frankincense is used by the Jordanian population as an aphrodisiac and a fertility promoting agent [29]. It may act on the pituitary gland and increase the main hormones of spermatogenesis. A significant increase in the sperm motility of cauda epididymis was observed in the treatment group, which may be due to the effect of frankincense on the enzymes of oxidative phosphorylation [29].*
Frankincense resins are believed to support healthy learning and memory on consumption, and it has been used by the elderly for memory enhancement and by pregnant women to enhance the memory and intelligence of their offspring [30].*
The essential oil isolated from the oleogum resin of Boswellia carterii has been found to have microbial supporting activities for gram-positive and gram-negative [31]. Type I diabetes is an autoimmune disease in which a chronic inflammatory process finally causes beta-cell death and insuIin deficiency. Extracts from the gum resin of B. serrata have been shown to support blood glucose balance. The study shows that Boswellia extract has blood glucose suppporting effects and could support a healthy liver and kidneys [32, 33].*

Active Constituents

Suggest Usage / Dosage

Ideal Storage Conditions

Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.

Shelf Life

Two years from date of manufacture.

References

Ni, Xiao et al. “Frankincense Essential Oil Prepared from Hydrodistillation of Boswellia Sacra Gum Resins Induces Human Pancreatic Cancer Cell Death in Cultures and in a Xenograft Murine Model.” BMC Complementary and Alternative Medicine 12 (2012): 253. PMC. Web. 23 Jan. 2018.
Shanghai Scientific and Technologic Press. Dictionary of Chinese Traditional Medicines. Tokyo, Japan: Shogakkan; 1985
Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri. Banno N, Akihisa T, Yasukawa K, Tokuda H, Tabata K, Nakamura Y, Nishimura R, Kimura Y, Suzuki T J Ethnopharmacol. 2006 Sep 19; 107(2):249-53.
Review article: complementary and alternative therapies for inflammatory bowel disease.Langmead L, Rampton DS Aliment Pharmacol Ther. 2006 Feb 1; 23(3):341-9.
Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro. Chevrier MR, Ryan AE, Lee DY, Zhongze M, Wu-Yan Z, Via CS Clin Diagn Lab Immunol. 2005 May; 12(5):575-80.
Effect of salai guggal ex-Boswellia serrata on cellular and humoral immune responses and leucocyte migration. Sharma ML, Khajuria A, Kaul A, Singh S, Singh GB, Atal CK Agents Actions. 1988 Jun; 24(1-2):161-4.
Screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance. Weckesser S, Engel K, Simon-Haarhaus B, Wittmer A, Pelz K, Schempp CM Phytomedicine. 2007 Aug; 14(7-8):508-16.
Boswellic acids inhibit glioma growth: a new treatment option?Winking M, Sarikaya S, Rahmanian A, Jödicke A, Böker DKJ Neurooncol. 2000; 46(2):97-103.
Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro. Hostanska K, Daum G, Saller R Anticancer Res. 2002 Sep-Oct; 22(5):2853-62.
Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid. Huang MT, Badmaev V, Ding Y, Liu Y, Xie JG, Ho CT Biofactors. 2000; 13(1-4):225-30.
Boswellic acids inhibit glioma growth: a new treatment option? Winking M, Sarikaya S, Rahmanian A, Jödicke A, Böker DK J Neurooncol. 2000; 46(2):97-103.
A lipoxygenase inhibitor in breast cancer brain metastases. Flavin DF J Neurooncol. 2007 Mar; 82(1):91-3.
Protection by boswellic acids against galactosamine/endotoxin-induced hepatitis in mice. Safayhi H, Mack T, Ammon HP Biochem Pharmacol. 1991 May 15; 41(10):1536-7.
Park YS, Lee JH, Bondar J, Harwalkar JA, Safayhi H, Golubic M. Cytotoxic action of acetyl-11-keto-β-boswellic acid (AKBA) on meningioma cells. Planta Medica. 2002;68:397–401. doi: 10.1055/s-2002-32090. [PubMed] [Cross Ref]
Shao Y, Ho CT, Chin CK, Badmaev V, Ma W, Huang MT. Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture. Planta Medica. 1998;64:328–331. doi: 10.1055/s-2006-957444. [PubMed] [Cross Ref]
Liu JJ, Nilsson A, Oredsson S, Badmaev V, Duan RD. Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway. Int J Mol Med. 2002;10:501–505. [PubMed]
Zhao W, Entschladen F, Liu H, Niggemann B, Fang Q, Zaenker KS, Han R. Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells. Cancer Detec Prev. 2003;27:67–75. doi: 10.1016/S0361-090X(02)00170-8. [PubMed] [Cross Ref]
Liu JJ, Nilsson A, Oredsson S, Badmaev V, Zhao WZ, Duan RD. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis. 2002;23:2087–2093. doi: 10.1093/carcin/23.12.2087. [PubMed] [Cross Ref]
Frank, Mark Barton et al. “Frankincense Oil Derived from Boswellia Carteri induces Tumor Cell Specific Cytotoxicity.” BMC Complementary and Alternative Medicine 9 (2009): 6. PMC. Web. 23 Jan. 2018.
Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Abdel-Tawab M, Werz O, Schubert-Zsilavecz M Clin Pharmacokinet. 2011 Jun; 50(6):349-69.
Bioactive constituents from Boswellia papyrifera. Atta-ur-Rahman, Naz H, Fadimatou, Makhmoor T, Yasin A, Fatima N, Ngounou FN, Kimbu SF, Sondengam BL, Choudhary MI J Nat Prod. 2005 Feb; 68(2):189-93.
Tadesse W, Desalegn G, Alia R. Natural gum and resin bearing species of Ethiopia and their potential applications. Investigación agraria. Sistemas y recursos forestales. 2007;16:211–221.
Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri.Akihisa T, Tabata K, Banno N, Tokuda H, Nishimura R, Nakamura Y, Kimura Y, Yasukawa K, Suzuki TBiol Pharm Bull. 2006 Sep; 29(9):1976-9.
Zhang, Yuxin et al. “Triterpenoid Resinous Metabolites from the Genus Boswellia: Pharmacological Activities and Potential Species-Identifying Properties.” Chemistry Central Journal 7 (2013): 153. PMC. Web. 23 Jan. 2018.
A-90 Day Gavage Safety Assessment of Boswellia serrata in Rats. Singh P, Chacko KM, Aggarwal ML, Bhat B, Khandal RK, Sultana S, Kuruvilla BT Toxicol Int. 2012 Sep; 19(3):273-8.
Sontakke S, Thawani V, Pimpalkhute S, Kabra P, Babhulkar S, Hingorani L. Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to vald**oxib in osteoarthritis of knee. Indian J Pharmacol. 2007;39:27. doi: 10.4103/0253-7613.30759
Cuaz-Perolin C, Billiet L, Bauge E, Copin C, Scott-Algara D, Genze F, et al. Antiinflammatory and antiatherogenic effects of the NF-kB inhibitor Acetyl-11-keto-B-Boswellic acid in LPS-challenged ApoE-/- Mice. Arterioscler Thromb Vasc Biol. 2008;28:272–7.
Nusier MK, Bataineh HN, Bataineh ZM, Daradka HM. Effect of frankincense (Boswellia thurifera) on reproductive system in adult male rat. J Health Sci. 2007;53:365–70.
Sharifabad MH, Esfandiari E, Alaei H. Effects of frankincense aqueous extract during gestational period on increasing power of learning and memory in adult offsprings. J Isfahan Med Sch. 2004;21:16–20.
Rahimi R, Shams-Ardekani MR, Abdollahi M. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol. 2010;16:4504–14
Shehata AM, Quintanilla-Fend L, Bettio S, Singh CB, Ammon HP. Prevention of Multiple Low-dose Streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia Serrata (BE) Phytomedicine. 2011;18:1037–44. [PubMed]
Ahmadpour F, Namjoyan F, Azemi M, Khodayar M, Darvish Padok A, Panahi M. Antioxidant capacity and anti-diabetic effect of Boswellia Serrata aqueous extract in female diabetic rats and the possible histological changes in the liver and kidney. Res Pharm Sci. 2012;7:17

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