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Cistanche Organic Extract (60%/22%/8% Phenylethanoid Glycosides)

Boosts Immune System*
Libido & Erection Support*
Enhanced Memory Support*
Healthy Kidney Function*
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Product Information

Cistanche species is a rare wild Chinese herb known as Rou Cong-Rong.

Legends state that the roots and stems of a desert plant called Cistanche tubulosa (also known as Rou Cong Rong in Chinese Medicine) were used not only to support sexual virility but to also directly support the quality of an erection. *

In the 10th century, a Chinese doctor invented many formulas for supporting optimal sexual activity in men. Each of the formulas contained more than 80% of this herb. *

In the legendary story of the "Battle of Thirteen Wings", Genghis Khan intended to unite Mongolia under one rule but his army was ambushed and felt exhausted and discouraged. All of a sudden, his army was attacked by white horses which came from the sky. His army started cutting the throats of the white horses and from the blood that stained the ground, Cistanche tubulosa was formed. *

This battle was seen as a sign from God that Khan’s army would be victorious. According to this legend, Genghis Khan consumed this desert plant daily after the battle. *

As a result of his consumption of this unusual herb plant, his sexual virility was said to have increased significantly. According to this legend, it is said that 8% of Asia's population are his direct descendants. According to this, and following today’s population, it means that 1 out of 200 people in China is a direct descendant of Genghis Khan. *

What is Cistanche?

Cistanche is a perennial parasite herb, associated with the roots of sand-fixing plants commonly seen in the arid lands and warm deserts of Northwestern China and other countries such as India, Iran, and Mongolia [1]. Cistanche is traditionally used in Chinese medicine as a tonic to support healthy kidneys, sexual function, and fertility in women as well as promoting healthy bowel movements[2]. Among all the tonics in Chinese medicine, Cistanche is extensively believed as the most important one and has even been given the name “Ginseng of the deserts.” It includes 22 species, but only 4 species, Cistanche deserticola, C. tubulosa, C. salsa and C. sinensis are believed to be beneficial for our health. Several compounds from these 4 species are found to support healthy aging and help in increasing libido in both men and women. Echinacoside and acteoside, which are two major compounds of phenylethanoid glycosides of Cistanche plant were found to possibly possess abundant wellness promoting activities. *

How could Cistanche Support My Health?

Modern pharmacological studies say that Cistanche possesses broad health benefits including, neuroprotection, antioxidation, liver health, immunomodulation, sexual function and bone health [3]. *
  • Among the species, Cistanche salsa may possess the most significant anti-aging properties. The anti-aging property is mainly attributed because of phenylethanoid glycosides and its components such as echinacoside, acteoside, isoacteoside and tubuloside [4]. They may help keep neuronal cells alive by maintaining proper mitochondrial function, improves the degradation of ROS, increase the expression of the anti-apoptotic protein Bcl-2 and inhibit caspase-3 activity through an antioxidative mechanism [5]. *
  • Aging in humans is associated with chronic low-grade cell degradation (systemic) state characterized by an increase in pro-inflammatory markers. Cistanche's active constituents showed remarkable support for healthy cell function, characterized by a significant reduction in markers such as myeloperoxidase, extracellular nucleosomes, high-mobility group box 1, cytokines; It also supports lipopolysaccharide-induced acute liver health. Acteoside and echinacoside are the main compounds that have healthy cell promoting properties and help support a healthy liver [6, 7]. *
  • One of the most challenging properties of health remedies is the ability to cross the blood-brain barrier freely. Cistanche may cross the blood-brain barrier easily, proving its potential in supporting brain health [8]. It increases expression of brain glial cells and supports cognitive function. *
  • The gradual loss of cognition is one of the main characteristics of aging. It is recorded that Cistanche could enhance the ability of learning and memorising [9] [10]. *
  • Cistanche could be used as a specific immunostimulatory adjuvant supporting healthy cell formation. Echinacoside exhibited an inhibitory effect on prostate cancer cell proliferation and suppressed the proliferation of pancreatic adenocarcinoma cells [12]. Immunomodulatory and anti-neoplastic effects of Cistanche are studied intensively. Acteoside of Cistanche is a potent immune support with extensive effects on immune organs, immune cells, and immune factors. [11]. *
  • Studies found that polysaccharides from Cistanche deserticola have an anti-hyperglycemic and hypolipidemic effect. Acteoside, acquired from the aqueous ethanol extract of the roots of Cistanche tubulosa, was involved in regulating the hypocholesterolemic activity and significantly improves the glucose tolerance in starch-loaded animal model experiment [13, 14]. Cistanche tubulosa has potent aldose reductase inhibitory activity and could significantly suppress elevated fasting blood glucose, postprandial blood glucose levels, improve insuIin resistance and dyslipidemia, as well as suppress body weight loss [15]. *
  • Cistanche violacea, a widespread bush found in Northern Africa, has remarkable bone support properties [16].
  • A recent study has demonstrated that an ethanol extract of C. tubulosa could increase sex hormone levels by inducing testicular steroidogenic enzymes [17]. The aphrodisiac mechanisms mainly because of acetosides and echinacoside. The acteoside of C. tubulosa enhances penis erection, increases the number of germ cells, and improves pathological changes in the testes [18]. Echinacoside possesses vaso-relaxing activity and has a positive effect on male hormone production [19]. Phenylethanoid Glycosides of Cistanche has shown significant improvement in sex hormone and has restored healthy function of the uterus. *
  • This “Desert ginseng” regular consumption is believed to be the key of people's longevity in some regions of China and Japan that were known for longevity and oasis [20]. More than ten percent of people suffer from at least one episode of depression and related mental disorders in a lifetime, and depression and related mental disorders are one of the world's greatest public health problems. The herb Cistanche showed potential to be used as a healthy mood support aid [21]. *
  • Hair health has decreased recently even in young people, seriously affecting individuals' quality of life. Cistanche tubulosa, a promising substance for promoting the health of the scalp and hair, at appropriate doses and ratios [22]. *

Active Compounds in Cistanche

Totally, 25 volatile compounds were identified in the essential oil of the Cistanche. Among them, 14-methylpentadecanoate (14%), ethyl palmitate (13%), and 2,5,6-trimethyloctane (8%) are the active and major constituents. In addition to that alkanes, alcohols, aldehydes, and heterocyclics were detected, and palmitic acid, linoleic acid, 14-methylpentadecanoate, ethyl palmitate, and 2,5,6-trimethyloctane were identified. Phenylethanoid glycosides, iridoids, lignans, alditols, oligosaccharides, cistanosides, and polysaccharides were the main constituents. 34 Phenylethanoid glycosides, 22 disaccharide glycosides, 10 trisaccharide glycosides, and 2 monosaccharide glycosides have been isolated in Cistanche. Small amounts of phenolic glycosides, sterols and their glycosides, fatty acids, amino acids, and trace elements, are also present in Cistanche.

Suggested Usage / Dosage

The recommended dosage for this extract is 100mg daily.

Ideal Storage Conditions

Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.

Shelf Life

2-years from Date of Manufacture.

References

  1. Li, Zhiming et al. “Herba Cistanche (Rou Cong-Rong): One of the Best Pharmaceutical Gifts of Traditional Chinese Medicine.” Frontiers in Pharmacology 7 (2016): 41. PMC. Web. 28 Feb. 2018.
  2. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Zhang CZ, Wang SX, Zhang Y, Chen JP, Liang XM. J Ethnopharmacol. 2005 Apr 26; 98(3):295-300.
  3. Wang, Ningqun et al. “Herba Cistanches: Anti-Aging.” Aging and Disease 8.6 (2017): 740–759. PMC. Web. 28 Feb. 2018.
  4. Echinacoside retards cellular senescence of human fibroblastic cells MRC-5. Xie H, Zhu H, Cheng C, Liang Y, Wang Z Pharmazie. 2009 Nov; 64(11):752-4.
  5. Phenylethanoid glycosides from Cistanches salsa inhibit apoptosis induced by 1-methyl-4-phenylpyridinium ion in neurons.Tian XF, Pu XP J Ethnopharmacol. 2005 Feb 10; 97(1):59-63.
  6. Protective effect of acteoside on immunological liver injury induced by Bacillus Calmette-Guerin plus lipopolysaccharide. Zhao J, Liu T, Ma L, Yan M, Zhao Y, Gu Z, Huang Y Planta Med. 2009 Nov; 75(14):1463-9.
  7. Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation.Li X, Gou C, Yang H, Qiu J, Gu T, Wen T Scand J Gastroenterol. 2014 Aug; 49(8):993-1000.
  8. Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone. Zhu M, Lu C, Li W J Neurochem. 2013 Feb; 124(4):571-80.
  9. Research on the effect of phenylethanoid glycosides (PEG) of the Cistanche deserticola on anti-aging in aged mice induced by D-galactose. Xuan GD, Liu CQ. Zhong Yao Cai. 2008 Sep; 31(9):1385-8.
  10. An open-label, nonplacebo-controlled study on Cistanche tubulosa glycoside capsules (Memoregain(®)) for treating moderate Alzheimer's Disease. Guo Q, Zhou Y, Wang CJ, Huang YM, Lee YT, Su MH, Lu J Am J Alzheimers Dis Other Demen. 2013 Jun; 28(4):363-70.
  11. Inhibitory effect of acteoside isolated from Cistanche tubulosa on chemical mediator release and inflammatory cytokine production by RBL-2H3 and KU812 cells. Yamada P, Iijima R, Han J, Shigemori H, Yokota S, Isoda H Planta Med. 2010 Oct; 76(14):1512-8.
  12. A general synthetic strategy and the anti-proliferation properties on prostate cancer cell lines for natural phenylethanoid glycosides. Mulani SK, Guh JH, Mong KK. Org Biomol Chem. 2014 May 14; 12(18):2926-37.
  13. Anti-hyperglycemic and hypolipidemic effects of Cistanche tubulosa in type 2 diabetic db/db mice. Xiong WT, Gu L, Wang C, Sun HX, Liu X. J Ethnopharmacol. 2013 Dec 12; 150(3):935-45.
  14. The hypocholesterolemic effects of Cistanche tubulosa extract, a Chinese traditional crude medicine, in mice. Shimoda H, Tanaka J, Takahara Y, Takemoto K, Shan SJ, Su MH Am J Chin Med. 2009; 37(6):1125-38.
  15. Anti-hyperglycemic and hypolipidemic effects of Cistanche tubulosa in type 2 diabetic db/db mice. Xiong WT, Gu L, Wang C, Sun HX, Liu X J Ethnopharmacol. 2013 Dec 12; 150(3):935-45.
  16. Chemical constituents and in vitro anti-inflammatory activity of Cistanche violacea Desf. (Orobanchaceae) extract. Bougandoura A, D'Abrosca B, Ameddah S, Scognamiglio M, Mekkiou R, Fiorentino A, Benayache S, Benayache F Fitoterapia. 2016 Mar; 109():248-53.
  17. Ma J. J., Zhao F., Sun Y. (2009). The effects of acteoside on nourishing kidney and strengthening Yang in Yang deficient mice. J. Yangzhou Univ. 30 22–25.
* Individual results may vary from person to person.