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Biotanica, Scutellaria Baicalensis Root, Premium Baicalin Extract

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Biotanica, Scutellaria Baicalensis Root, Premium Baicalin Extract

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Supports Positive Cell Function.*
Promotes Normal Immune Response.*
Healthy Cognitive Function.*
May Promote Calm Mind.*
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Product Description
Baicalin is a flavone extract obtained from the purification of the dried root of Scutellaria baicalensis and other species of genus Scutellaria,.It is native to Asian countries(China & Japan). Baicalein is an aglycone product of baicalin. It is also called skull cap in the US. Baicalin is a flavone gotten through the cleaving of glucuronic acid to baicalein. It can also be called baicalein -7-0-glucuronide, with a molecular mass of 446.4 g/mol [2].

It is a common health supplement in china and japan. The extract is being used in Chinese traditional medicine to promote good eyesight and in aiding normal skin health in psoriasis. Native Americans used the extract to aid breathing and also promote normal gastrointestinal functions. The extract is sold as a tea, supplement, and tincture in herbalist shops. Due to its ability to support normal calming cell responses, it has received interest from scientists. Historically, In traditional eastern medicine, the dried root of the skull cap has been used to promote various healthy functions of the body.  
Product Benefits

Eye and skin benefits

The leading cause of blindness in the world has been reported to be some ocular diseases like cataract, glaucoma, and the likes. Geriatric (Elderly) people are at the risk of suffering age-related macular degeneration. Reports suggest that flavonoids' dietary intake could help slow the process that leads to ocular degradation [4]. The extract was observed to reduce oxidative stress, thereby improving skin quality. Study suggests that it promotes the process that leads to mopping up of free radicals, thus aiding the skin regeneration [5]. When the extract is used with other cosmetics, it supports skin health and smoothness. Experts suggest that, it could have a favorable action against acne [3].

Joint Health

Rheumatoid arthritis is an inflammatory and auto-immune disease. Rheumatoid arthritis patients are at risk of coming down with coronary artery disease. Research suggests that baicalin could promote healthy cell response in patients with rheumatoid arthritis, thereby alleviating the condition. In a study, it was noticed to reduce swelling in the ankles of rats, thus validating its use in rheumatism. The extract was also observed to promote normal cell response in patients with an inflamed joint. The extract was reported to support normal cell response in a rheumatic joint by not aiding the NF-κB p65 subunit's synovial expression. Despite its reported potentials, there are still weak claims to corroborate those facts [6].

Cell Replication Health

Baicalin was observed to promote healthy replication of cells in cell issues with women. The extract inhibited the process that might support ovarian cancer cell viability. It plays an important role in slowing down the tumorigenicity of some cells by modulating and down-regulating several signal pathways. The extract has also been beneficial in breast cancer through its cogent role in suppressing migration and adhesion caused by cancer. The herb was reported to aid the process that leads to the programmed death of cancerous cells (Apoptosis) in patients with prostate cancer. In a concentration-dependent manner, it was observed to play a significant part in the inhibition of basic-fibroblast growth factor-induced angiogenesis. Compared to other alternatives, it has a very low side effect. Scientists have been looking for a way to formulate the extract to improve the extract's bioavailability [7].

Anti-Microbial activity

Several studies and researches have been done to validate its use against bacteria and other micro-organisms. The plant extract has been observed to be both bacteriostatic and bactericidal, depending on the concentration. The herb extract was noticed to work synergistically with other beta-lactam penicillin (amoxicillin, etc.) against the methicillin-resistant Staphylococcus aureus (MRSA). The herb extract was noticed to have beneficial action against Mycobacterium tuberculosis. Due to its potent activity against the bacteria, it induces autophagy to promote normal respiratory function in patients with tuberculosis. Patients with tuberculosis do secrete excess pro-inflammatory cytokines, which results in inflammatory and immunological changes. The extract reduces the changes by inducing the process that will lead to a reduction in the pro-inflammatory cytokines. When used as adjunctive therapy with other anti-microbial agents, it worked synergistically[8].

Restful Sleep

The herb promotes sleep and also improves the quality of sleep. The extract has a significant role in decreasing sleep latency at night. Its ability to enhance sleep quality is due to its significant role in the inhibition of gamma-aminobutyric acid (GABA) in the day and promotion of GABA activities in the night [9]. Baicalin has also been reported to promote heart health and then enhance memory.  
Nutritional Profile

It is a medicinal food that is rich in flavonoids [10].

References

1. Puya Y. (December,2018). Baicalin& Baicalein : Potential benefits & Upcoming research. Retrieved from : https://selfhacked.com/blog/baicalein-baicalin-top-7-health-benefits-flavanoid/

2. National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 64982, Baicalin. Retrieved July 27, 2020 from https://pubchem.ncbi.nlm.nih.gov/compound/Baicalin.

3. Ultimo .A ( 04-11-2018). All the benefits of baicalon, a natural anti-aging product . Retrieved from: https://wellness-trends.com/benefits-baicalin-natural-anti-aging-product/health/

4. Xiao, J. R., Do, C. W., & To, C. H. (2014). Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 30(8), 605–614. https://doi.org/10.1089/jop.2014.0074

5. Zhou, Bing-Rong, et al. "Baicalin protects human fibroblasts against ultraviolet B-induced cyclobutane pyrimidine dimers formation." Archives of dermatological research 300.6 (2008): 331-334

6. Hang, Y., Qin, X., Ren, T., & Cao, J. (2018). Baicalin reduces blood lipids and inflammation in patients with coronary artery disease and rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Lipids in health and disease, 17(1), 146. https://doi.org/10.1186/s12944-018-0797-2

7. Moore, O. A., Gao, Y., Chen, A. Y., Brittain, R., & Chen, Y. C. (2016). The Extraction, Anticancer Effect, Bioavailability, and Nanotechnology of Baicalin. Journal of nutritional medicine and diet care, 2(1),
8. https://doi.org/10.23937/2572-3278.1510011 8. Alonso, S., Pethe, K., Russell, D. G., and Purdy, G. E. (2007). Lysosomal killing of mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy. Proc. Natl. Acad. Sci. U.S.A. 104, 6031–6036. doi: 10.1073/pnas.0700036104
9. Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., & Chang, F. C. (2011). Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. Journal of ethnopharmacology, 135(2), 359–368. https://doi.org/10.1016/j.jep.2011.03.023
10. National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 64982, Baicalin. Retrieved July 27, 2020 from https://pubchem.ncbi.nlm.nih.gov/compound/Baicalin.

Suggested Use
Take up to 1200mg Twice Daily.
Interactions & Warnings
Always consult with your doctor or health professional before changing your health regime.
Shelf Life
2 Years from Date of Manufacture.
Storage
Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 m

Delivery Methods

We ship worldwide using NZ Post Priority and Express Tracked mail service. All orders placed with us are tracked so that you can find your order at any time, once it has been dispatched.

Delivery Time
Most orders are shipped by 4 PM within two business days. If for some reason we cannot ship your order by 4 PM within two business days, we will email you to let you know within 48 hours.

NZ Delivery Time
All New Zealand orders are tracked. Please allow for 2 business days for processing and packaging, with 3 - 5 business days to arrive.

USA Delivery Time
We use tracked Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent

Canada Delivery Time
We use tracked Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent

Australia Delivery Time
We use tracked Priority shipping which may take up to 6 - 8 days. Please allow for 2 business days for processing and packaging before your order is sent.

All Other International Countries Delivery Time
We use Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent.
Returns With Us Are Easy

Biotanica® maintains a total customer satisfaction guarantee on all Biotanica® auto-delivery products. If you, the customer, are unhappy with the product for any reason, you can return the unused item(s) for a full refund of the purchase price minus delivery and handling. To obtain your refund, you must email us at: returns@BiotanicaHealth.com with your order number so we can process your refund.

Your order number can easily be found next to your name on grey package it arrived in.

To receive your refund, your return must be received at our delivery facility within 30 days of purchase. You pay for return delivery.

Please send your package to:

Biotanica® Health
P O Box 147200
Ponsonby
Auckland
1011
New Zealand

We will not accept or issue a refund for any packages marked return to sender or refused. If you return a package, we recommend that you get proof of shipment. Upon receipt of your returned product, a refund will be issued to your credit card.

After the delivery department receives your return, it generally takes 3 - 5 business days or less to process your refund. Once a return is processed, it can take up to one billing cycle for the refund to be posted to your account, depending on your financial banking institution.

Here are 5 more great reasons to buy from us:

You get a full 30 days to return your item to us. If it's not right for you, you've changed your mind or for no reason whatsoever simply send it back to us and we'll cheerfully refund your order less any applicable bank and service fees.

Returns are easy, simply click here for our returns policy. We'll get you a replacement or refund in a snap!

In the unlikely event that you find your item cheaper at another online store, just let us know and we'll beat the competitor's pricing hands-down.

We insist that you love everything you buy from us. If you're unhappy for any reason whatsoever, just let us know and we'll bend over backwards to make things right again.

Ordering from Biotanica® is 100% safe and secure so you can rest easy. Your personal details are never shared, sold or rented to anyone.

Product Description
Baicalin is a flavone extract obtained from the purification of the dried root of Scutellaria baicalensis and other species of genus Scutellaria,.It is native to Asian countries(China & Japan). Baicalein is an aglycone product of baicalin. It is also called skull cap in the US. Baicalin is a flavone gotten through the cleaving of glucuronic acid to baicalein. It can also be called baicalein -7-0-glucuronide, with a molecular mass of 446.4 g/mol [2].

It is a common health supplement in china and japan. The extract is being used in Chinese traditional medicine to promote good eyesight and in aiding normal skin health in psoriasis. Native Americans used the extract to aid breathing and also promote normal gastrointestinal functions. The extract is sold as a tea, supplement, and tincture in herbalist shops. Due to its ability to support normal calming cell responses, it has received interest from scientists. Historically, In traditional eastern medicine, the dried root of the skull cap has been used to promote various healthy functions of the body.  
Product Benefits

Eye and skin benefits

The leading cause of blindness in the world has been reported to be some ocular diseases like cataract, glaucoma, and the likes. Geriatric (Elderly) people are at the risk of suffering age-related macular degeneration. Reports suggest that flavonoids' dietary intake could help slow the process that leads to ocular degradation [4]. The extract was observed to reduce oxidative stress, thereby improving skin quality. Study suggests that it promotes the process that leads to mopping up of free radicals, thus aiding the skin regeneration [5]. When the extract is used with other cosmetics, it supports skin health and smoothness. Experts suggest that, it could have a favorable action against acne [3].

Joint Health

Rheumatoid arthritis is an inflammatory and auto-immune disease. Rheumatoid arthritis patients are at risk of coming down with coronary artery disease. Research suggests that baicalin could promote healthy cell response in patients with rheumatoid arthritis, thereby alleviating the condition. In a study, it was noticed to reduce swelling in the ankles of rats, thus validating its use in rheumatism. The extract was also observed to promote normal cell response in patients with an inflamed joint. The extract was reported to support normal cell response in a rheumatic joint by not aiding the NF-κB p65 subunit's synovial expression. Despite its reported potentials, there are still weak claims to corroborate those facts [6].

Cell Replication Health

Baicalin was observed to promote healthy replication of cells in cell issues with women. The extract inhibited the process that might support ovarian cancer cell viability. It plays an important role in slowing down the tumorigenicity of some cells by modulating and down-regulating several signal pathways. The extract has also been beneficial in breast cancer through its cogent role in suppressing migration and adhesion caused by cancer. The herb was reported to aid the process that leads to the programmed death of cancerous cells (Apoptosis) in patients with prostate cancer. In a concentration-dependent manner, it was observed to play a significant part in the inhibition of basic-fibroblast growth factor-induced angiogenesis. Compared to other alternatives, it has a very low side effect. Scientists have been looking for a way to formulate the extract to improve the extract's bioavailability [7].

Anti-Microbial activity

Several studies and researches have been done to validate its use against bacteria and other micro-organisms. The plant extract has been observed to be both bacteriostatic and bactericidal, depending on the concentration. The herb extract was noticed to work synergistically with other beta-lactam penicillin (amoxicillin, etc.) against the methicillin-resistant Staphylococcus aureus (MRSA). The herb extract was noticed to have beneficial action against Mycobacterium tuberculosis. Due to its potent activity against the bacteria, it induces autophagy to promote normal respiratory function in patients with tuberculosis. Patients with tuberculosis do secrete excess pro-inflammatory cytokines, which results in inflammatory and immunological changes. The extract reduces the changes by inducing the process that will lead to a reduction in the pro-inflammatory cytokines. When used as adjunctive therapy with other anti-microbial agents, it worked synergistically[8].

Restful Sleep

The herb promotes sleep and also improves the quality of sleep. The extract has a significant role in decreasing sleep latency at night. Its ability to enhance sleep quality is due to its significant role in the inhibition of gamma-aminobutyric acid (GABA) in the day and promotion of GABA activities in the night [9]. Baicalin has also been reported to promote heart health and then enhance memory.  
Nutritional Profile

It is a medicinal food that is rich in flavonoids [10].

References

1. Puya Y. (December,2018). Baicalin& Baicalein : Potential benefits & Upcoming research. Retrieved from : https://selfhacked.com/blog/baicalein-baicalin-top-7-health-benefits-flavanoid/

2. National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 64982, Baicalin. Retrieved July 27, 2020 from https://pubchem.ncbi.nlm.nih.gov/compound/Baicalin.

3. Ultimo .A ( 04-11-2018). All the benefits of baicalon, a natural anti-aging product . Retrieved from: https://wellness-trends.com/benefits-baicalin-natural-anti-aging-product/health/

4. Xiao, J. R., Do, C. W., & To, C. H. (2014). Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 30(8), 605–614. https://doi.org/10.1089/jop.2014.0074

5. Zhou, Bing-Rong, et al. "Baicalin protects human fibroblasts against ultraviolet B-induced cyclobutane pyrimidine dimers formation." Archives of dermatological research 300.6 (2008): 331-334

6. Hang, Y., Qin, X., Ren, T., & Cao, J. (2018). Baicalin reduces blood lipids and inflammation in patients with coronary artery disease and rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Lipids in health and disease, 17(1), 146. https://doi.org/10.1186/s12944-018-0797-2

7. Moore, O. A., Gao, Y., Chen, A. Y., Brittain, R., & Chen, Y. C. (2016). The Extraction, Anticancer Effect, Bioavailability, and Nanotechnology of Baicalin. Journal of nutritional medicine and diet care, 2(1),
8. https://doi.org/10.23937/2572-3278.1510011 8. Alonso, S., Pethe, K., Russell, D. G., and Purdy, G. E. (2007). Lysosomal killing of mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy. Proc. Natl. Acad. Sci. U.S.A. 104, 6031–6036. doi: 10.1073/pnas.0700036104
9. Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., & Chang, F. C. (2011). Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. Journal of ethnopharmacology, 135(2), 359–368. https://doi.org/10.1016/j.jep.2011.03.023
10. National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 64982, Baicalin. Retrieved July 27, 2020 from https://pubchem.ncbi.nlm.nih.gov/compound/Baicalin.

Suggested Use
Take up to 1200mg Twice Daily.
Interactions & Warnings
Always consult with your doctor or health professional before changing your health regime.
Shelf Life
2 Years from Date of Manufacture.
Storage
Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 m

Delivery Methods

We ship worldwide using NZ Post Priority and Express Tracked mail service. All orders placed with us are tracked so that you can find your order at any time, once it has been dispatched.

Delivery Time
Most orders are shipped by 4 PM within two business days. If for some reason we cannot ship your order by 4 PM within two business days, we will email you to let you know within 48 hours.

NZ Delivery Time
All New Zealand orders are tracked. Please allow for 2 business days for processing and packaging, with 3 - 5 business days to arrive.

USA Delivery Time
We use tracked Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent

Canada Delivery Time
We use tracked Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent

Australia Delivery Time
We use tracked Priority shipping which may take up to 6 - 8 days. Please allow for 2 business days for processing and packaging before your order is sent.

All Other International Countries Delivery Time
We use Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent.
Returns With Us Are Easy

Biotanica® maintains a total customer satisfaction guarantee on all Biotanica® auto-delivery products. If you, the customer, are unhappy with the product for any reason, you can return the unused item(s) for a full refund of the purchase price minus delivery and handling. To obtain your refund, you must email us at: returns@BiotanicaHealth.com with your order number so we can process your refund.

Your order number can easily be found next to your name on grey package it arrived in.

To receive your refund, your return must be received at our delivery facility within 30 days of purchase. You pay for return delivery.

Please send your package to:

Biotanica® Health
P O Box 147200
Ponsonby
Auckland
1011
New Zealand

We will not accept or issue a refund for any packages marked return to sender or refused. If you return a package, we recommend that you get proof of shipment. Upon receipt of your returned product, a refund will be issued to your credit card.

After the delivery department receives your return, it generally takes 3 - 5 business days or less to process your refund. Once a return is processed, it can take up to one billing cycle for the refund to be posted to your account, depending on your financial banking institution.

Here are 5 more great reasons to buy from us:

You get a full 30 days to return your item to us. If it's not right for you, you've changed your mind or for no reason whatsoever simply send it back to us and we'll cheerfully refund your order less any applicable bank and service fees.

Returns are easy, simply click here for our returns policy. We'll get you a replacement or refund in a snap!

In the unlikely event that you find your item cheaper at another online store, just let us know and we'll beat the competitor's pricing hands-down.

We insist that you love everything you buy from us. If you're unhappy for any reason whatsoever, just let us know and we'll bend over backwards to make things right again.

Ordering from Biotanica® is 100% safe and secure so you can rest easy. Your personal details are never shared, sold or rented to anyone.

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