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Kanna (10:1) Extract

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Mood & Relaxation Support*
Stress & Anxiety Support*
Potent Natural SSRI*
Appetite Management*
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Sceletium Tortuosum is a medicinal plant from South Africa. It's also a succulent commonly known as Kanna, Channa, and Kougoed.

What is Kanna?

Kanna is a herb considered by many as the king of mood support remedies. Kanna (literally meaning "something to chew") is used by the ancient hunting tribes of San and Khoi [1]. In 1738, Kanna was said to be the "greatest cheerer of the spirits, and the noblest restorative in the world" [3]. Tinctures of this plant were reported to be commonly used by colonists in the Cape of Good Hope [9]. By ethnopharmacological standards, this plant has been well-reviewed for the past few decades. It has attracted many in the U.S. due to its hypothesized applications in promoting a sense of well-being and relieving stress in healthy individuals. It is also commonly used to support abdominal health, stave off hunger, and enhance moods. More recently, it has attracted wider scientific attention as a possible management compound for mood, relaxation and stress support [2]. *

How Could Kanna Extract Support My Health?

Over the past 15 years, an increasing number of Sceletium-based products, including teas, tinctures, tablets, capsules, and raw powdered plant material, are often sold over the Internet. Evidently, it is being used by healthy individuals to promote a sense of well-being and relieve stress [8]. Packages of S. tortuosum tea bags, often in combination with Red Bush Tea (Aspalathus linearis) or Honeybush tea (Cyclopia spp.) are sold in South African supermarkets. *

Clinical depression is an increasingly prevalent problem in the U.S., with 1 out of 10 adults reported to having some form of the depressive disorder (CDC, 2008). Kanna has been shown to be effective as a natural mood support remedy. Mesembrine and mesembrenone are the most predominant alkaloids present in this extract. Much evidence has been presented to show that these compounds contain anxiolytic effects, acts as a mood enhancement, and generally promotes a positive well-being [4]. *

Mesembrine and mesembrenone were discovered to be serotonin-uptake inhibitors. Standardized amounts of these compounds have been used potentially for the management and support of mental health [5]. *

It is scientifically proven that Kanna exerts significant cell protection effects against toxin stimulations. Kanna has displayed positive effects on immune cell function. Simon Chiu et al, 2014 studied the efficacy of the Kanna extract for neurocognitive effects. The extract has promising cognitive-enhancing effects [6]. *

Intake of the Kanna extract (about 50 mg per day for 4 months) has been shown to support a healthy appetite, weight management, restful sleep, energy levels, stress, emotional health and a sense of well-being [2]. *

Regular consumption of 50 mg per day for 10 days can significantly change the lifestyle of those wishing to support their moods. Reports showed that major symptoms such as feeling despondent, social withdrawal, feeling tearful and empty, and a feeling of pervasive sadness maybe supported with intake of the Kanna extract [2]. *

Stress-related illnesses rate among the most prevalent non-fatal diseases globally. Swart and Smith's (2016) data suggest the potentially beneficial effects of Kanna extract, which is rich in mesembrine (1% of plant extract), in the context of a healthy response to stress. This extract has displayed a significant role in the inhibition of rising cortisol levels [7]. *

Nutritive Value of Kanna Extract

This plant is rich in carbohydrates, protein, fatty acids and alkaloids. There are four major alkaloids found in Kanna extract: mesembrine, mesembrenone, mesembrenol, and mesembranol. These are some of the alkaloids that possess several pharmacological properties. Other alkaloids often named in the literature include tortuosamine, sceletium A4, chennaine, 4’-O-demethylmesembranol, sceletone, joubertiamine, and hordenine.

Kanna extract is also high in total mineral content. Among the minerals present, iron and calcium can be seen in larger quantities.

Suggested Usage / Dosage

The recommended dosage for this extract is 50 - 200 mg daily. You are advised to not exceed the recommended dosage.

Interactions / Side Effects

A high dose can cause headaches with some abdominal pain, nausea, and upper respiratory tract infections. No adverse side effects or withdrawal effects have been reported by long-term users of the herb.

Ideal Storage Conditions

Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.

Shelf Life

2-years from Date of Manufacture.

References

  1. Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review.Smith MT, Crouch NR, Gericke N, Hirst M. J Ethnopharmacol. 1996 Mar; 50(3):119-30.
  2. Sceletium--a review update.Gericke N, Viljoen AM J Ethnopharmacol. 2008 Oct 28; 119(3):653-63.
  3. Scott G, Springfield EP (2004). "Pharmaceutical monographs for 60 South African plant species used as traditional medicines". South African National Biodiversity Institute (SANBI) Plant Information.
  4. Zhang,H.(2009).Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs. Current Pharmaceutical Design, 15(14), 1688.
  5. Van Wyk B-E, de Wet H, Van Heerden FR. An ethnobotanical survey of medicinal plants in the southeastern Karoo, South Africa. South African J Bot. 2008;74(4):696-704. doi:https://doi.org/10.1016/j.sajb.2008.05.001.
  6. Chiu S, Gericke N, Farina-Woodbury M, et al. Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia. Evidence-based Complementary and Alternative Medicine?: eCAM. 2014;2014:682014. doi:10.1155/2014/682014.
  7. Swart AC, Smith C. Modulation of glucocorticoid, mineralocorticoid and androgen production in H295 cells by Trimesemine, a mesembrine-rich Sceletium extract. J Ethnopharmacol. 2016;177:35-45. doi:10.1016/j.jep.2015.11.033.
  8. Gericke, N., Viljoen, A.M., 2008. Sceletium—a review update. J. Ethnopharmacol. 119 (3), 653–663.
  9. Pappe, L. 1868. Mesembryanthemum tortuosum Lin. In: Florae Capensis Medicae Prodromus; or, An Enumeration of South African Plants Used As Remedies By The Colonists Of The Cape Of Good Hope. Third Edition, Paragraph 39, page 17. W. Brittain, Bureau Street, Cape Town
  10. Shikanga, E., Viljoen, A., Combrinck, S., Marston, A., Gericke, N., 2012. The chemotypic variation of Sceletium tortuosum alkaloids and commercial product formulations. Biochem. Syst. Ecol. 44, 364–373.

   
Delivery Methods

We ship worldwide using NZ Post Priority and Express Tracked mail service. All orders placed with us are tracked so that you can find your order at any time, once it has been dispatched.

Delivery Time
Most orders are shipped by 4 PM within two business days. If for some reason we cannot ship your order by 4 PM within two business days, we will email you to let you know within 48 hours.

NZ Delivery Time
All New Zealand orders are tracked. Please allow for 2 business days for processing and packaging, with 3 - 5 business days to arrive.

USA Delivery Time
We use tracked Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent

Canada Delivery Time
We use tracked Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent

Australia Delivery Time
We use tracked Priority shipping which may take up to 6 - 8 days. Please allow for 2 business days for processing and packaging before your order is sent.

All Other International Countries Delivery Time
We use Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent.
Returns With Us Are Easy

Biotanica® maintains a total customer satisfaction guarantee on all Biotanica® auto-delivery products. If you, the customer, are unhappy with the product for any reason, you can return the unused item(s) for a full refund of the purchase price minus delivery and handling. To obtain your refund, you must email us at: returns@BiotanicaHealth.com with your order number so we can process your refund.

Your order number can easily be found next to your name on grey package it arrived in.

To receive your refund, your return must be received at our delivery facility within 30 days of purchase. You pay for return delivery.

Please send your package to:

Biotanica® Health
P O Box 147200
Ponsonby
Auckland
1011
New Zealand

We will not accept or issue a refund for any packages marked return to sender or refused. If you return a package, we recommend that you get proof of shipment. Upon receipt of your returned product, a refund will be issued to your credit card.

After the delivery department receives your return, it generally takes 3 - 5 business days or less to process your refund. Once a return is processed, it can take up to one billing cycle for the refund to be posted to your account, depending on your financial banking institution.

Here are 5 more great reasons to buy from us:

   

You get a full 30 days to return your item to us. If it's not right for you, you've changed your mind or for no reason whatsoever simply send it back to us and we'll cheerfully refund your order less any applicable bank and service fees.

Returns are easy, simply click here for our returns policy. We'll get you a replacement or refund in a snap!

In the unlikely event that you find your item cheaper at another online store, just let us know and we'll beat the competitor's pricing hands-down.

We insist that you love everything you buy from us. If you're unhappy for any reason whatsoever, just let us know and we'll bend over backwards to make things right again.

Ordering from Biotanica® is 100% safe and secure so you can rest easy. Your personal details are never shared, sold or rented to anyone.

Sceletium Tortuosum is a medicinal plant from South Africa. It's also a succulent commonly known as Kanna, Channa, and Kougoed.

What is Kanna?

Kanna is a herb considered by many as the king of mood support remedies. Kanna (literally meaning "something to chew") is used by the ancient hunting tribes of San and Khoi [1]. In 1738, Kanna was said to be the "greatest cheerer of the spirits, and the noblest restorative in the world" [3]. Tinctures of this plant were reported to be commonly used by colonists in the Cape of Good Hope [9]. By ethnopharmacological standards, this plant has been well-reviewed for the past few decades. It has attracted many in the U.S. due to its hypothesized applications in promoting a sense of well-being and relieving stress in healthy individuals. It is also commonly used to support abdominal health, stave off hunger, and enhance moods. More recently, it has attracted wider scientific attention as a possible management compound for mood, relaxation and stress support [2]. *

How Could Kanna Extract Support My Health?

Over the past 15 years, an increasing number of Sceletium-based products, including teas, tinctures, tablets, capsules, and raw powdered plant material, are often sold over the Internet. Evidently, it is being used by healthy individuals to promote a sense of well-being and relieve stress [8]. Packages of S. tortuosum tea bags, often in combination with Red Bush Tea (Aspalathus linearis) or Honeybush tea (Cyclopia spp.) are sold in South African supermarkets. *

Clinical depression is an increasingly prevalent problem in the U.S., with 1 out of 10 adults reported to having some form of the depressive disorder (CDC, 2008). Kanna has been shown to be effective as a natural mood support remedy. Mesembrine and mesembrenone are the most predominant alkaloids present in this extract. Much evidence has been presented to show that these compounds contain anxiolytic effects, acts as a mood enhancement, and generally promotes a positive well-being [4]. *

Mesembrine and mesembrenone were discovered to be serotonin-uptake inhibitors. Standardized amounts of these compounds have been used potentially for the management and support of mental health [5]. *

It is scientifically proven that Kanna exerts significant cell protection effects against toxin stimulations. Kanna has displayed positive effects on immune cell function. Simon Chiu et al, 2014 studied the efficacy of the Kanna extract for neurocognitive effects. The extract has promising cognitive-enhancing effects [6]. *

Intake of the Kanna extract (about 50 mg per day for 4 months) has been shown to support a healthy appetite, weight management, restful sleep, energy levels, stress, emotional health and a sense of well-being [2]. *

Regular consumption of 50 mg per day for 10 days can significantly change the lifestyle of those wishing to support their moods. Reports showed that major symptoms such as feeling despondent, social withdrawal, feeling tearful and empty, and a feeling of pervasive sadness maybe supported with intake of the Kanna extract [2]. *

Stress-related illnesses rate among the most prevalent non-fatal diseases globally. Swart and Smith's (2016) data suggest the potentially beneficial effects of Kanna extract, which is rich in mesembrine (1% of plant extract), in the context of a healthy response to stress. This extract has displayed a significant role in the inhibition of rising cortisol levels [7]. *

Nutritive Value of Kanna Extract

This plant is rich in carbohydrates, protein, fatty acids and alkaloids. There are four major alkaloids found in Kanna extract: mesembrine, mesembrenone, mesembrenol, and mesembranol. These are some of the alkaloids that possess several pharmacological properties. Other alkaloids often named in the literature include tortuosamine, sceletium A4, chennaine, 4’-O-demethylmesembranol, sceletone, joubertiamine, and hordenine.

Kanna extract is also high in total mineral content. Among the minerals present, iron and calcium can be seen in larger quantities.

Suggested Usage / Dosage

The recommended dosage for this extract is 50 - 200 mg daily. You are advised to not exceed the recommended dosage.

Interactions / Side Effects

A high dose can cause headaches with some abdominal pain, nausea, and upper respiratory tract infections. No adverse side effects or withdrawal effects have been reported by long-term users of the herb.

Ideal Storage Conditions

Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.

Shelf Life

2-years from Date of Manufacture.

References

  1. Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review.Smith MT, Crouch NR, Gericke N, Hirst M. J Ethnopharmacol. 1996 Mar; 50(3):119-30.
  2. Sceletium--a review update.Gericke N, Viljoen AM J Ethnopharmacol. 2008 Oct 28; 119(3):653-63.
  3. Scott G, Springfield EP (2004). "Pharmaceutical monographs for 60 South African plant species used as traditional medicines". South African National Biodiversity Institute (SANBI) Plant Information.
  4. Zhang,H.(2009).Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs. Current Pharmaceutical Design, 15(14), 1688.
  5. Van Wyk B-E, de Wet H, Van Heerden FR. An ethnobotanical survey of medicinal plants in the southeastern Karoo, South Africa. South African J Bot. 2008;74(4):696-704. doi:https://doi.org/10.1016/j.sajb.2008.05.001.
  6. Chiu S, Gericke N, Farina-Woodbury M, et al. Proof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer’s Dementia. Evidence-based Complementary and Alternative Medicine?: eCAM. 2014;2014:682014. doi:10.1155/2014/682014.
  7. Swart AC, Smith C. Modulation of glucocorticoid, mineralocorticoid and androgen production in H295 cells by Trimesemine, a mesembrine-rich Sceletium extract. J Ethnopharmacol. 2016;177:35-45. doi:10.1016/j.jep.2015.11.033.
  8. Gericke, N., Viljoen, A.M., 2008. Sceletium—a review update. J. Ethnopharmacol. 119 (3), 653–663.
  9. Pappe, L. 1868. Mesembryanthemum tortuosum Lin. In: Florae Capensis Medicae Prodromus; or, An Enumeration of South African Plants Used As Remedies By The Colonists Of The Cape Of Good Hope. Third Edition, Paragraph 39, page 17. W. Brittain, Bureau Street, Cape Town
  10. Shikanga, E., Viljoen, A., Combrinck, S., Marston, A., Gericke, N., 2012. The chemotypic variation of Sceletium tortuosum alkaloids and commercial product formulations. Biochem. Syst. Ecol. 44, 364–373.

   
Delivery Methods

We ship worldwide using NZ Post Priority and Express Tracked mail service. All orders placed with us are tracked so that you can find your order at any time, once it has been dispatched.

Delivery Time
Most orders are shipped by 4 PM within two business days. If for some reason we cannot ship your order by 4 PM within two business days, we will email you to let you know within 48 hours.

NZ Delivery Time
All New Zealand orders are tracked. Please allow for 2 business days for processing and packaging, with 3 - 5 business days to arrive.

USA Delivery Time
We use tracked Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent

Canada Delivery Time
We use tracked Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent

Australia Delivery Time
We use tracked Priority shipping which may take up to 6 - 8 days. Please allow for 2 business days for processing and packaging before your order is sent.

All Other International Countries Delivery Time
We use Priority shipping which may take up to 8 - 12 days. For Express Orders please allow for 4 - 6 days for delivery. Please allow for 2 business days for processing and packaging before your order is sent.
Returns With Us Are Easy

Biotanica® maintains a total customer satisfaction guarantee on all Biotanica® auto-delivery products. If you, the customer, are unhappy with the product for any reason, you can return the unused item(s) for a full refund of the purchase price minus delivery and handling. To obtain your refund, you must email us at: returns@BiotanicaHealth.com with your order number so we can process your refund.

Your order number can easily be found next to your name on grey package it arrived in.

To receive your refund, your return must be received at our delivery facility within 30 days of purchase. You pay for return delivery.

Please send your package to:

Biotanica® Health
P O Box 147200
Ponsonby
Auckland
1011
New Zealand

We will not accept or issue a refund for any packages marked return to sender or refused. If you return a package, we recommend that you get proof of shipment. Upon receipt of your returned product, a refund will be issued to your credit card.

After the delivery department receives your return, it generally takes 3 - 5 business days or less to process your refund. Once a return is processed, it can take up to one billing cycle for the refund to be posted to your account, depending on your financial banking institution.

Here are 5 more great reasons to buy from us:

   

You get a full 30 days to return your item to us. If it's not right for you, you've changed your mind or for no reason whatsoever simply send it back to us and we'll cheerfully refund your order less any applicable bank and service fees.

Returns are easy, simply click here for our returns policy. We'll get you a replacement or refund in a snap!

In the unlikely event that you find your item cheaper at another online store, just let us know and we'll beat the competitor's pricing hands-down.

We insist that you love everything you buy from us. If you're unhappy for any reason whatsoever, just let us know and we'll bend over backwards to make things right again.

Ordering from Biotanica® is 100% safe and secure so you can rest easy. Your personal details are never shared, sold or rented to anyone.

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